Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study
The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days. Animals were s...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2015/164943 |
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| author | Gaurav Gupta Tay Jia Jia Lim Yee Woon Dinesh Kumar Chellappan Mayuren Candasamy Kamal Dua |
| author_facet | Gaurav Gupta Tay Jia Jia Lim Yee Woon Dinesh Kumar Chellappan Mayuren Candasamy Kamal Dua |
| author_sort | Gaurav Gupta |
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| description | The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days. Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten. Acute treatment of all treatment groups did not significantly reduce the immobility time (p>0.05). Chronic treatment of combination of genistein (10 mg/kg) and amitriptyline (5 mg/kg and 10 mg/kg) significantly reduced the immobility time as compared to control group (p<0.001) and was comparable to amitriptyline alone (10 mg/kg). However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5 mg/kg) and amitriptyline (5 mg/kg) were observed. Genistein at its standard dose (10 mg/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5 mg/kg) and additive effects in combination with therapeutic dose of amitriptyline (10 mg/kg). |
| format | Article |
| id | doaj-art-0b25da8134784892a1b487d42341d7be |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-0b25da8134784892a1b487d42341d7be2025-02-03T01:01:37ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422015-01-01201510.1155/2015/164943164943Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic StudyGaurav Gupta0Tay Jia Jia1Lim Yee Woon2Dinesh Kumar Chellappan3Mayuren Candasamy4Kamal Dua5Department of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Life Science, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaSchool of Biomedical Science, University of Newcastle, Newcastle, NSW 2308, AustraliaThe present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone or in combination for ten days. Animals were subjected to locomotor activity testing; tail suspension test (TST); and forced swim test (FST) and immobility time was recorded on day one and day ten. Acute treatment of all treatment groups did not significantly reduce the immobility time (p>0.05). Chronic treatment of combination of genistein (10 mg/kg) and amitriptyline (5 mg/kg and 10 mg/kg) significantly reduced the immobility time as compared to control group (p<0.001) and was comparable to amitriptyline alone (10 mg/kg). However, no changes in anti-immobility activity in combination of subeffective doses of genistein (5 mg/kg) and amitriptyline (5 mg/kg) were observed. Genistein at its standard dose (10 mg/kg) rendered synergistic effects in combination with subeffective dose of amitriptyline (5 mg/kg) and additive effects in combination with therapeutic dose of amitriptyline (10 mg/kg).http://dx.doi.org/10.1155/2015/164943 |
| spellingShingle | Gaurav Gupta Tay Jia Jia Lim Yee Woon Dinesh Kumar Chellappan Mayuren Candasamy Kamal Dua Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study Advances in Pharmacological Sciences |
| title | Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study |
| title_full | Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study |
| title_fullStr | Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study |
| title_full_unstemmed | Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study |
| title_short | Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study |
| title_sort | pharmacological evaluation of antidepressant like effect of genistein and its combination with amitriptyline an acute and chronic study |
| url | http://dx.doi.org/10.1155/2015/164943 |
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