The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis
Osteoporosis is a disease that decreases bone mass. The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs. Osteoporosis treatment is all-important in preventing bone loss. One strategy for osteoporosis...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/132436 |
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| author | Kwang-Jin Kim Alain Simplice Leutou Jeong-Tae Yeon Sik-Won Choi Seong Hwan Kim Sung-Tae Yee Kyung Hee Choi Sang-Jip Nam Young-Jin Son |
| author_facet | Kwang-Jin Kim Alain Simplice Leutou Jeong-Tae Yeon Sik-Won Choi Seong Hwan Kim Sung-Tae Yee Kyung Hee Choi Sang-Jip Nam Young-Jin Son |
| author_sort | Kwang-Jin Kim |
| collection | DOAJ |
| description | Osteoporosis is a disease that decreases bone mass. The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs. Osteoporosis treatment is all-important in preventing bone loss. One strategy for osteoporosis treatment is to inhibit osteoclastogenesis. Osteoclasts are bone-resorbing multinucleated cells, and overactive osteoclasts and/or their increased number are observed in bone disorders including osteoporosis and rheumatoid arthritis. Bioactivity-guided fractionations led to the isolation of alisol A 24-acetate from the dried tuber of Alisma canaliculatum. Alisol A 24-acetate inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1, which plays an essential role in osteoclast differentiation. Furthermore, it inhibited the expression of DC-STAMP and cathepsin K, which are related to cell-cell fusion of osteoclasts and bone resorption, respectively. Therefore, alisol A 24-acetate could be developed as a new structural scaffold for inhibitors of osteoclast differentiation in order to develop new drugs against osteoporosis. |
| format | Article |
| id | doaj-art-0b2301de674346939ba3e059154ec68e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0b2301de674346939ba3e059154ec68e2025-02-03T06:05:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/132436132436The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on OsteoclastogenesisKwang-Jin Kim0Alain Simplice Leutou1Jeong-Tae Yeon2Sik-Won Choi3Seong Hwan Kim4Sung-Tae Yee5Kyung Hee Choi6Sang-Jip Nam7Young-Jin Son8Department of Pharmacy, Sunchon National University, Suncheon, Jeonnam 540-742, Republic of KoreaDepartment of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of KoreaResearch Institute of Basic Science, Sunchon National University, Suncheon 540-742, Republic of KoreaLaboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of KoreaLaboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon, Jeonnam 540-742, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon, Jeonnam 540-742, Republic of KoreaDepartment of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon, Jeonnam 540-742, Republic of KoreaOsteoporosis is a disease that decreases bone mass. The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs. Osteoporosis treatment is all-important in preventing bone loss. One strategy for osteoporosis treatment is to inhibit osteoclastogenesis. Osteoclasts are bone-resorbing multinucleated cells, and overactive osteoclasts and/or their increased number are observed in bone disorders including osteoporosis and rheumatoid arthritis. Bioactivity-guided fractionations led to the isolation of alisol A 24-acetate from the dried tuber of Alisma canaliculatum. Alisol A 24-acetate inhibited RANKL-mediated osteoclast differentiation by downregulating NFATc1, which plays an essential role in osteoclast differentiation. Furthermore, it inhibited the expression of DC-STAMP and cathepsin K, which are related to cell-cell fusion of osteoclasts and bone resorption, respectively. Therefore, alisol A 24-acetate could be developed as a new structural scaffold for inhibitors of osteoclast differentiation in order to develop new drugs against osteoporosis.http://dx.doi.org/10.1155/2015/132436 |
| spellingShingle | Kwang-Jin Kim Alain Simplice Leutou Jeong-Tae Yeon Sik-Won Choi Seong Hwan Kim Sung-Tae Yee Kyung Hee Choi Sang-Jip Nam Young-Jin Son The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis International Journal of Endocrinology |
| title | The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis |
| title_full | The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis |
| title_fullStr | The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis |
| title_full_unstemmed | The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis |
| title_short | The Inhibitory Effect of Alisol A 24-Acetate from Alisma canaliculatum on Osteoclastogenesis |
| title_sort | inhibitory effect of alisol a 24 acetate from alisma canaliculatum on osteoclastogenesis |
| url | http://dx.doi.org/10.1155/2015/132436 |
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