Spectrophotometric Determination of Ezetimibe
Two simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. Method A and B are based on the redox/complex formation reaction of drug with 1,10-phenanthr...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/238140 |
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| author | P. Baby Sudha Lakshmi D. Ramchandran C. Rambabu |
| author_facet | P. Baby Sudha Lakshmi D. Ramchandran C. Rambabu |
| author_sort | P. Baby Sudha Lakshmi |
| collection | DOAJ |
| description | Two simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. Method A and B are based on the redox/complex formation reaction of drug with 1,10-phenanthroline and hexacyano-ferrate(III) in presence of ferric chloride to form coloured chromogens exhibiting λmax at 510 and 740 nm respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The results are compared with those obtained using UV spectrophotometric method in alcohol at 231.7 nm. |
| format | Article |
| id | doaj-art-0b229c89fca34acbaaa8e747d546a22d |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0b229c89fca34acbaaa8e747d546a22d2025-02-03T06:05:09ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017110110410.1155/2010/238140Spectrophotometric Determination of EzetimibeP. Baby Sudha Lakshmi0D. Ramchandran1C. Rambabu2Department of Chemistry, Acharya Nagarjuna University, Nuzvid Campus, Nuzvid-521201. A.P, IndiaDepartment of Chemistry, Acharya Nagarjuna University, Nuzvid Campus, Nuzvid-521201. A.P, IndiaDepartment of Chemistry, Acharya Nagarjuna University, Nuzvid Campus, Nuzvid-521201. A.P, IndiaTwo simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. Method A and B are based on the redox/complex formation reaction of drug with 1,10-phenanthroline and hexacyano-ferrate(III) in presence of ferric chloride to form coloured chromogens exhibiting λmax at 510 and 740 nm respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The results are compared with those obtained using UV spectrophotometric method in alcohol at 231.7 nm.http://dx.doi.org/10.1155/2010/238140 |
| spellingShingle | P. Baby Sudha Lakshmi D. Ramchandran C. Rambabu Spectrophotometric Determination of Ezetimibe E-Journal of Chemistry |
| title | Spectrophotometric Determination of Ezetimibe |
| title_full | Spectrophotometric Determination of Ezetimibe |
| title_fullStr | Spectrophotometric Determination of Ezetimibe |
| title_full_unstemmed | Spectrophotometric Determination of Ezetimibe |
| title_short | Spectrophotometric Determination of Ezetimibe |
| title_sort | spectrophotometric determination of ezetimibe |
| url | http://dx.doi.org/10.1155/2010/238140 |
| work_keys_str_mv | AT pbabysudhalakshmi spectrophotometricdeterminationofezetimibe AT dramchandran spectrophotometricdeterminationofezetimibe AT crambabu spectrophotometricdeterminationofezetimibe |