Mediators of increased blood flow in porcine skin
Nicotinates and benzalkonium chloride (B.Cl) cause inflammatory changes in human skin, thought to be dependent upon prostaglandin formation. This study has examined the effects of hexyl-nicotinate (HN) and B.Cl on blood flow in porcine skin. The role of prostaglandins and interleukin (IL)-1 in the b...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000115 |
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| _version_ | 1832559118335868928 |
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| author | H. D. Moore F. M. Cunningham |
| author_facet | H. D. Moore F. M. Cunningham |
| author_sort | H. D. Moore |
| collection | DOAJ |
| description | Nicotinates and benzalkonium chloride (B.Cl) cause inflammatory changes in human skin, thought to be dependent upon prostaglandin formation. This study has examined the effects of hexyl-nicotinate (HN) and B.Cl on blood flow in porcine skin. The role of prostaglandins and interleukin (IL)-1 in the blood flow response has been investigated. Blood flow was increased by both HN and B.Cl, the response to B.Cl being more protracted. Cyclooxygenase inhibitor pretreatment reduced these responses. IL-1-like biological activity was identified in normal porcine epidermis and the amounts recovered from inflamed skin were similar. Thus prostaglandin formation in HN or B.Cl-induced inflammation, if IL-1 dependent, is not associated with the loss of significant amounts of the cytokine from the epidermis. |
| format | Article |
| id | doaj-art-0b11d675a2f54af6ace7ad517a2dc3ca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0b11d675a2f54af6ace7ad517a2dc3ca2025-02-03T01:30:46ZengWileyMediators of Inflammation0962-93511466-18611992-01-0111555910.1155/S0962935192000115Mediators of increased blood flow in porcine skinH. D. Moore0F. M. Cunningham1Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, UKDepartment of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, UKNicotinates and benzalkonium chloride (B.Cl) cause inflammatory changes in human skin, thought to be dependent upon prostaglandin formation. This study has examined the effects of hexyl-nicotinate (HN) and B.Cl on blood flow in porcine skin. The role of prostaglandins and interleukin (IL)-1 in the blood flow response has been investigated. Blood flow was increased by both HN and B.Cl, the response to B.Cl being more protracted. Cyclooxygenase inhibitor pretreatment reduced these responses. IL-1-like biological activity was identified in normal porcine epidermis and the amounts recovered from inflamed skin were similar. Thus prostaglandin formation in HN or B.Cl-induced inflammation, if IL-1 dependent, is not associated with the loss of significant amounts of the cytokine from the epidermis.http://dx.doi.org/10.1155/S0962935192000115 |
| spellingShingle | H. D. Moore F. M. Cunningham Mediators of increased blood flow in porcine skin Mediators of Inflammation |
| title | Mediators of increased blood flow in porcine skin |
| title_full | Mediators of increased blood flow in porcine skin |
| title_fullStr | Mediators of increased blood flow in porcine skin |
| title_full_unstemmed | Mediators of increased blood flow in porcine skin |
| title_short | Mediators of increased blood flow in porcine skin |
| title_sort | mediators of increased blood flow in porcine skin |
| url | http://dx.doi.org/10.1155/S0962935192000115 |
| work_keys_str_mv | AT hdmoore mediatorsofincreasedbloodflowinporcineskin AT fmcunningham mediatorsofincreasedbloodflowinporcineskin |