Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa
Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms wer...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2015/979631 |
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| author | Daméhan Tchelougou Jonas K. Kologo Simplice D. Karou Valentin N. Yaméogo Cyrille Bisseye Florencia W. Djigma Djeneba Ouermi Tegwindé R. Compaoré Maléki Assih Virginio Pietra Patrice Zabsonré Jacques Simpore |
| author_facet | Daméhan Tchelougou Jonas K. Kologo Simplice D. Karou Valentin N. Yaméogo Cyrille Bisseye Florencia W. Djigma Djeneba Ouermi Tegwindé R. Compaoré Maléki Assih Virginio Pietra Patrice Zabsonré Jacques Simpore |
| author_sort | Daméhan Tchelougou |
| collection | DOAJ |
| description | Objective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10−4). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients. |
| format | Article |
| id | doaj-art-0b10d091864a450189bb0780be70f633 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-0b10d091864a450189bb0780be70f6332025-02-03T01:00:21ZengWileyInternational Journal of Hypertension2090-03842090-03922015-01-01201510.1155/2015/979631979631Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West AfricaDaméhan Tchelougou0Jonas K. Kologo1Simplice D. Karou2Valentin N. Yaméogo3Cyrille Bisseye4Florencia W. Djigma5Djeneba Ouermi6Tegwindé R. Compaoré7Maléki Assih8Virginio Pietra9Patrice Zabsonré10Jacques Simpore11Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoService de Cardiologie, CHU-Yalgado Ouédraogo, BP 7022, Ouagadougou 03, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoService de Cardiologie, CHU-Yalgado Ouédraogo, BP 7022, Ouagadougou 03, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoService de Cardiologie, CHU-Yalgado Ouédraogo, BP 7022, Ouagadougou 03, Burkina FasoCentre de Recherche Biomoléculaire Pietro Annigoni (CERBA), BP 364, Ouagadougou 01, Burkina FasoObjective. This study aimed to investigate the association between three polymorphisms of renin-angiotensin system and the essential hypertension in the population of Burkina Faso. Methodology. This was a case-control study including 202 cases and 204 matched controls subjects. The polymorphisms were identified by a classical and a real-time PCR. Results. The AGT 235M/T and AT1R 1166A/C polymorphisms were not associated with the hypertension while the genotype frequencies of the ACE I/D polymorphism between patients and controls (DD: 66.83% and 35.78%, ID: 28.22% and 50.98%, II: 4.95% and 13.24%, resp.) were significantly different (p < 10−4). The genotype DD of ACE gene (OR = 3.40, p < 0.0001), the increasing age (OR = 3.83, p < 0.0001), obesity (OR = 4.84, p < 0.0001), dyslipidemia (OR = 3.43, p = 0.021), and alcohol intake (OR = 2.76, p < 0.0001) were identified as the independent risk factors for hypertension by multinomial logistic regression. Conclusion. The DD genotype of the ACE gene is involved in susceptibility to hypertension. Further investigations are needed to better monitor and provide individualized care for hypertensive patients.http://dx.doi.org/10.1155/2015/979631 |
| spellingShingle | Daméhan Tchelougou Jonas K. Kologo Simplice D. Karou Valentin N. Yaméogo Cyrille Bisseye Florencia W. Djigma Djeneba Ouermi Tegwindé R. Compaoré Maléki Assih Virginio Pietra Patrice Zabsonré Jacques Simpore Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa International Journal of Hypertension |
| title | Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa |
| title_full | Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa |
| title_fullStr | Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa |
| title_full_unstemmed | Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa |
| title_short | Renin-Angiotensin System Genes Polymorphisms and Essential Hypertension in Burkina Faso, West Africa |
| title_sort | renin angiotensin system genes polymorphisms and essential hypertension in burkina faso west africa |
| url | http://dx.doi.org/10.1155/2015/979631 |
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