Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study
Objectives To estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).Design A cross-sectional study.Setting PLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Provin...
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BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e059316.full |
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| author | Jie Yuan Hai Long Min Liu Juan He Jue Liu Yu Wu Wenzhan Jing Min Du Manna Zhang Yaping Wang Su Song Siqi Liu Guiying Cao Yuedong Liang Xiaoxin Xie Yanhua Fu |
| author_facet | Jie Yuan Hai Long Min Liu Juan He Jue Liu Yu Wu Wenzhan Jing Min Du Manna Zhang Yaping Wang Su Song Siqi Liu Guiying Cao Yuedong Liang Xiaoxin Xie Yanhua Fu |
| author_sort | Jie Yuan |
| collection | DOAJ |
| description | Objectives To estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).Design A cross-sectional study.Setting PLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021.Participants A total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study.Primary and secondary outcome measures Anaemia was diagnosed as a haemoglobin concentration <120 g/L for non-pregnant females and <130 g/L for males. Mild, moderate and severe anaemia were diagnosed as below the gender‐specific lower limit of normal but ≥110 g/L, 80–110 g/L and <80 g/L, respectively.Results The prevalence of anaemia was 27.5%, and that of mild, moderate and severe anaemia was 9.2%, 12.2% and 6.1%, respectively. Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. Widowed or divorced inpatients (anaemia: aOR=1.26, 95% CI: 1.08 to 1.47; severe anaemia: aOR=1.52, 95% CI: 1.16 to 1.97) and thrombocytopenia inpatients (anaemia: aOR=4.25, 95% CI: 3.54 to 5.10; severe anaemia: aOR=4.16, 95% CI: 3.24 to 5.35) had increased odds of anaemia and severe anaemia compared with their counterparts. Hepatitis C was associated with increased odds of severe anaemia (aOR=1.80, 95% CI: 1.11 to 2.92).Conclusions Anaemia was prevalent among hospitalised PLHIV. Female sex, those widowed or divorced, and thrombocytopenia were associated with increased odds of anaemia, and those widowed or divorced, thrombocytopenia and hepatitis C were associated with increased odds of severe anaemia. Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression. |
| format | Article |
| id | doaj-art-0afa9fa24045495ab714240962e9a99b |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0afa9fa24045495ab714240962e9a99b2025-01-30T13:00:15ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2021-059316Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional studyJie Yuan0Hai Long1Min Liu2Juan He3Jue Liu4Yu Wu5Wenzhan Jing6Min Du7Manna Zhang8Yaping Wang9Su Song10Siqi Liu11Guiying Cao12Yuedong Liang13Xiaoxin Xie14Yanhua Fu151 State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, China1Chongqing University Cancer Hospital, Department of Radiation Oncology, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China2Providence Therapeutics Holdings, Inc., Calgary, AB, CanadaDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, ChinaKey Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaDepartment of Infectious Diseases, Public Health Center of Guiyang, Guiyang, Guizhou, ChinaObjectives To estimate anaemia prevalence and the associated factors among hospitalised people living with HIV (PLHIV) receiving antiretroviral therapy (ART).Design A cross-sectional study.Setting PLHIV receiving ART and hospitalised in a specialised hospital for infectious disease in Guizhou Province, Southwest China, between 1 January 2018 and 31 March 2021.Participants A total of 6959 hospitalised PLHIV aged ≥18 years and receiving ART were included in this study.Primary and secondary outcome measures Anaemia was diagnosed as a haemoglobin concentration <120 g/L for non-pregnant females and <130 g/L for males. Mild, moderate and severe anaemia were diagnosed as below the gender‐specific lower limit of normal but ≥110 g/L, 80–110 g/L and <80 g/L, respectively.Results The prevalence of anaemia was 27.5%, and that of mild, moderate and severe anaemia was 9.2%, 12.2% and 6.1%, respectively. Results from multivariate logistic regression showed that females had increased odds of anaemia (adjusted OR (aOR)=1.60, 95% CI: 1.42 to 1.81) compared with males. Widowed or divorced inpatients (anaemia: aOR=1.26, 95% CI: 1.08 to 1.47; severe anaemia: aOR=1.52, 95% CI: 1.16 to 1.97) and thrombocytopenia inpatients (anaemia: aOR=4.25, 95% CI: 3.54 to 5.10; severe anaemia: aOR=4.16, 95% CI: 3.24 to 5.35) had increased odds of anaemia and severe anaemia compared with their counterparts. Hepatitis C was associated with increased odds of severe anaemia (aOR=1.80, 95% CI: 1.11 to 2.92).Conclusions Anaemia was prevalent among hospitalised PLHIV. Female sex, those widowed or divorced, and thrombocytopenia were associated with increased odds of anaemia, and those widowed or divorced, thrombocytopenia and hepatitis C were associated with increased odds of severe anaemia. Determination of anaemia predictors, early detection and timely management of anaemia are crucial to prevent anaemia progression.https://bmjopen.bmj.com/content/12/7/e059316.full |
| spellingShingle | Jie Yuan Hai Long Min Liu Juan He Jue Liu Yu Wu Wenzhan Jing Min Du Manna Zhang Yaping Wang Su Song Siqi Liu Guiying Cao Yuedong Liang Xiaoxin Xie Yanhua Fu Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study BMJ Open |
| title | Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study |
| title_full | Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study |
| title_fullStr | Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study |
| title_full_unstemmed | Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study |
| title_short | Prevalence of anaemia and the associated factors among hospitalised people living with HIV receiving antiretroviral therapy in Southwest China: a cross-sectional study |
| title_sort | prevalence of anaemia and the associated factors among hospitalised people living with hiv receiving antiretroviral therapy in southwest china a cross sectional study |
| url | https://bmjopen.bmj.com/content/12/7/e059316.full |
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