Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study
In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zol...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/8597062 |
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| author | Praveen Sripad Jessica Rosenberg Frank Boers Christian P. Filss Norbert Galldiks Karl-Josef Langen Ralf Clauss N. Jon Shah Jürgen Dammers |
| author_facet | Praveen Sripad Jessica Rosenberg Frank Boers Christian P. Filss Norbert Galldiks Karl-Josef Langen Ralf Clauss N. Jon Shah Jürgen Dammers |
| author_sort | Praveen Sripad |
| collection | DOAJ |
| description | In the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI. |
| format | Article |
| id | doaj-art-0af9a7653a884471a55704d530830d1b |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-0af9a7653a884471a55704d530830d1b2025-02-03T06:46:00ZengWileyCase Reports in Neurological Medicine2090-66682090-66762020-01-01202010.1155/2020/85970628597062Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG StudyPraveen Sripad0Jessica Rosenberg1Frank Boers2Christian P. Filss3Norbert Galldiks4Karl-Josef Langen5Ralf Clauss6N. Jon Shah7Jürgen Dammers8Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyNuclear Medicine Department, Royal Surrey County Hospital, Guildford, Surrey GU2 7XX, UKInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, GermanyIn the past two decades, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI.http://dx.doi.org/10.1155/2020/8597062 |
| spellingShingle | Praveen Sripad Jessica Rosenberg Frank Boers Christian P. Filss Norbert Galldiks Karl-Josef Langen Ralf Clauss N. Jon Shah Jürgen Dammers Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study Case Reports in Neurological Medicine |
| title | Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study |
| title_full | Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study |
| title_fullStr | Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study |
| title_full_unstemmed | Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study |
| title_short | Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study |
| title_sort | effect of zolpidem in the aftermath of traumatic brain injury an meg study |
| url | http://dx.doi.org/10.1155/2020/8597062 |
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