Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia

Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia

<b>Background</b>: Uricase, or urate oxidase (Uox) is a key enzyme in uric acid (UA) metabolism and has been applied in clinical treatment of human hyperuricemia (HUA). However, the current clinically applied uricases, despite their potent urate-lowering capacity, tend to form anti-drug...

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Main Authors: Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
Subjects:
uricase
hyperuricemia
macrophage therapy
engineered macrophages
Online Access:https://www.mdpi.com/2227-9059/12/11/2602
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