Current Trends in the Molecular Classification of Renal Neoplasms
Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines his...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.390 |
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| _version_ | 1832548518982582272 |
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| author | Andrew N. Young Viraj A. Master Mahul B. Amin |
| author_facet | Andrew N. Young Viraj A. Master Mahul B. Amin |
| author_sort | Andrew N. Young |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. However, light microscopic diagnosis of RCC subtypes is often difficult due to variable histology. In addition, the clinical behavior of RCC is highly variable and therapeutic response rates are poor. Few clinical assays are available to predict outcome in RCC or correlate behavior with histology. Therefore, novel RCC classification systems based on gene expression should be useful for diagnosis, prognosis, and treatment. Recent microarray studies have shown that renal tumors are characterized by distinct gene expression profiles, which can be used to discover novel diagnostic and prognostic biomarkers. Here, we review clinical features of kidney cancer, the WHO classification system, and the growing role of molecular classification for diagnosis, prognosis, and therapy of this disease. |
| format | Article |
| id | doaj-art-0af3a9847c834db2aef4e524bdfd03f3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0af3a9847c834db2aef4e524bdfd03f32025-02-03T06:13:49ZengWileyThe Scientific World Journal1537-744X2006-01-0162505251810.1100/tsw.2006.390Current Trends in the Molecular Classification of Renal NeoplasmsAndrew N. Young0Viraj A. Master1Mahul B. Amin2Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USADepartment of Urology, Emory University School of Medicine, Atlanta, GA, USADepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CARenal cell carcinoma (RCC) is the most common form of kidney cancer in adults. RCC is a significant challenge for pathologic diagnosis and clinical management. The primary approach to diagnosis is by light microscopy, using the World Health Organization (WHO) classification system, which defines histopathologic tumor subtypes with distinct clinical behavior and underlying genetic mutations. However, light microscopic diagnosis of RCC subtypes is often difficult due to variable histology. In addition, the clinical behavior of RCC is highly variable and therapeutic response rates are poor. Few clinical assays are available to predict outcome in RCC or correlate behavior with histology. Therefore, novel RCC classification systems based on gene expression should be useful for diagnosis, prognosis, and treatment. Recent microarray studies have shown that renal tumors are characterized by distinct gene expression profiles, which can be used to discover novel diagnostic and prognostic biomarkers. Here, we review clinical features of kidney cancer, the WHO classification system, and the growing role of molecular classification for diagnosis, prognosis, and therapy of this disease.http://dx.doi.org/10.1100/tsw.2006.390 |
| spellingShingle | Andrew N. Young Viraj A. Master Mahul B. Amin Current Trends in the Molecular Classification of Renal Neoplasms The Scientific World Journal |
| title | Current Trends in the Molecular Classification of Renal Neoplasms |
| title_full | Current Trends in the Molecular Classification of Renal Neoplasms |
| title_fullStr | Current Trends in the Molecular Classification of Renal Neoplasms |
| title_full_unstemmed | Current Trends in the Molecular Classification of Renal Neoplasms |
| title_short | Current Trends in the Molecular Classification of Renal Neoplasms |
| title_sort | current trends in the molecular classification of renal neoplasms |
| url | http://dx.doi.org/10.1100/tsw.2006.390 |
| work_keys_str_mv | AT andrewnyoung currenttrendsinthemolecularclassificationofrenalneoplasms AT virajamaster currenttrendsinthemolecularclassificationofrenalneoplasms AT mahulbamin currenttrendsinthemolecularclassificationofrenalneoplasms |