A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment
Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-11-01
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| Series: | Mycobiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/12298093.2024.2416736 |
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| author | Khushbu Wadhwa Neha Kapoor Hardeep Kaur Eman A. Abu-Seer Mohd. Tariq Sazada Siddiqui Virendra Kumar Yadav Parwiz Niazi Pankaj Kumar Saad Alghamdi |
| author_facet | Khushbu Wadhwa Neha Kapoor Hardeep Kaur Eman A. Abu-Seer Mohd. Tariq Sazada Siddiqui Virendra Kumar Yadav Parwiz Niazi Pankaj Kumar Saad Alghamdi |
| author_sort | Khushbu Wadhwa |
| collection | DOAJ |
| description | Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of their growth, which are categorized into terpenoids, alkaloids, polyketides, and non-ribosomal peptides. These SMs exhibit significant biological activity, which contributes to the formulation of novel pharmaceuticals, biopesticides, and environmental bioremediation agents. Nowadays, these fungal-derived SMs are widely used in food and beverages, for fermentation, preservatives, protein sources, and in dairy industries. In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. The present review comprehensively analyses the diversity of fungal SMs along with their emerging applications in healthcare, agriculture, environmental sustainability, and nutraceuticals. Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. Finally, the authors have addressed the potential for genetic manipulation and biotechnological innovations for further exploitation of fungal SMs for commercial and environmental benefits. |
| format | Article |
| id | doaj-art-0aef50befc7046f4989b03b35dedb609 |
| institution | Kabale University |
| issn | 1229-8093 2092-9323 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycobiology |
| spelling | doaj-art-0aef50befc7046f4989b03b35dedb6092025-01-19T13:49:31ZengTaylor & Francis GroupMycobiology1229-80932092-93232024-11-0152633538710.1080/12298093.2024.2416736A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and EnvironmentKhushbu Wadhwa0Neha Kapoor1Hardeep Kaur2Eman A. Abu-Seer3Mohd. Tariq4Sazada Siddiqui5Virendra Kumar Yadav6Parwiz Niazi7Pankaj Kumar8Saad Alghamdi9Department of Zoology, Ramjas College, University of Delhi, Delhi, IndiaDepartment of Chemistry, Hindu College, University of Delhi, Delhi, IndiaDepartment of Zoology, Ramjas College, University of Delhi, Delhi, IndiaDepartment of Epidemiology and Medical Statistics, Faculty of Public Health and Health Informatics, Umm Al-Qura University, Mecca, Saudi ArabiaDepartment of Life Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat, IndiaDepartment of Biology, College of Science, King Khalid University, Abha, Saudi ArabiaMarwadi University Research Center, Department of Microbiology, Faculty of Sciences, Marwadi University, Rajkot, Gujarat, IndiaDepartment of Biology, Faculty of Education, Kandahar University, Kandahar, AfghanistanDepartment of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat, IndiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi ArabiaFungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to their increasing applications in healthcare, environmental cleanup, and biotechnology-based industries. The fungi produce these secondary metabolites (SMs) during the different phases of their growth, which are categorized into terpenoids, alkaloids, polyketides, and non-ribosomal peptides. These SMs exhibit significant biological activity, which contributes to the formulation of novel pharmaceuticals, biopesticides, and environmental bioremediation agents. Nowadays, these fungal-derived SMs are widely used in food and beverages, for fermentation, preservatives, protein sources, and in dairy industries. In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. The present review comprehensively analyses the diversity of fungal SMs along with their emerging applications in healthcare, agriculture, environmental sustainability, and nutraceuticals. Here, the authors have reviewed the recent advancements in genetic engineering, metabolic pathway manipulation, and synthetic biology to improve the production and yield of these SMs. Advancement in fermentation techniques, bioprocessing, and co-cultivation approaches for large-scale production of SMs. Investigators further highlighted the importance of omics technologies in understanding the regulation and biosynthesis of SMs, which offers an understanding of novel applications in drug discovery and sustainable agriculture. Finally, the authors have addressed the potential for genetic manipulation and biotechnological innovations for further exploitation of fungal SMs for commercial and environmental benefits.https://www.tandfonline.com/doi/10.1080/12298093.2024.2416736Secondary metabolitesmycoproteinhuman healthgene clustersmycofiltration |
| spellingShingle | Khushbu Wadhwa Neha Kapoor Hardeep Kaur Eman A. Abu-Seer Mohd. Tariq Sazada Siddiqui Virendra Kumar Yadav Parwiz Niazi Pankaj Kumar Saad Alghamdi A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment Mycobiology Secondary metabolites mycoprotein human health gene clusters mycofiltration |
| title | A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment |
| title_full | A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment |
| title_fullStr | A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment |
| title_full_unstemmed | A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment |
| title_short | A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment |
| title_sort | comprehensive review of the diversity of fungal secondary metabolites and their emerging applications in healthcare and environment |
| topic | Secondary metabolites mycoprotein human health gene clusters mycofiltration |
| url | https://www.tandfonline.com/doi/10.1080/12298093.2024.2416736 |
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