Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children
<b>Background:</b> This study investigates bacterial etiology and antibiotic resistance in pediatric leukemia patients to determine the impact of chronic pathology on treatment efficacy. <b>Methods</b>: Thirty cases of children aged 1–16 years (18 boys, 12 girls) were analyze...
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2024-12-01
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| author | Cristina Elena Singer Alin Iulian Silviu Popescu Renata Maria Văruț Mihaela Popescu Dira Loredana Kristina Radivojevic Petrescu Ileana Octavia |
| author_facet | Cristina Elena Singer Alin Iulian Silviu Popescu Renata Maria Văruț Mihaela Popescu Dira Loredana Kristina Radivojevic Petrescu Ileana Octavia |
| author_sort | Cristina Elena Singer |
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| description | <b>Background:</b> This study investigates bacterial etiology and antibiotic resistance in pediatric leukemia patients to determine the impact of chronic pathology on treatment efficacy. <b>Methods</b>: Thirty cases of children aged 1–16 years (18 boys, 12 girls) were analyzed, identifying 13 pathogens, including 8 Gram-positive and 5 Gram-negative bacteria. <b>Results</b>: Among the patients, 11 girls presented with acute lymphoblastic leukemia (ALL) type B, while one boy and one girl had acute myeloid leukemia, and, as for boys, three had ALL type T and two had pre-B ALL. The most common pathogens were methicillin-resistant <i>Staphylococcus aureus</i> (MRSA, 11 patients), methicillin-sensitive <i>Staphylococcus aureus</i> (MSSA, 6 patients), <i>Klebsiella</i> spp., and <i>Staphylococcus epidermidis</i>. Due to the patients’ compromised health, most required intensive care and strong antibiotic regimens, including linezolid, vancomycin, and ertapenem, which showed limited resistance. <b>Conclusions</b>: These findings highlight the critical importance of understanding bacterial resistance patterns to guide effective treatments in vulnerable populations. Knowing specific resistance profiles can be lifesaving, allowing for tailored therapies that improve survival rates in children with leukemia facing serious bacterial infections. Focusing on the dual aspects of pediatric patients and multidrug-resistant bacterial infections, this study aims to highlight the importance of addressing these factors together to enhance therapeutic approaches in vulnerable populations. |
| format | Article |
| id | doaj-art-0ae78ef3fd264ba5babef7652ed8109a |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-0ae78ef3fd264ba5babef7652ed8109a2025-08-20T02:00:59ZengMDPI AGAntibiotics2079-63822024-12-011312123410.3390/antibiotics13121234Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised ChildrenCristina Elena Singer0Alin Iulian Silviu Popescu1Renata Maria Văruț2Mihaela Popescu3Dira Loredana4Kristina Radivojevic5Petrescu Ileana Octavia6Department of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaResearch Methodology Department, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Endocrinology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaFaculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania<b>Background:</b> This study investigates bacterial etiology and antibiotic resistance in pediatric leukemia patients to determine the impact of chronic pathology on treatment efficacy. <b>Methods</b>: Thirty cases of children aged 1–16 years (18 boys, 12 girls) were analyzed, identifying 13 pathogens, including 8 Gram-positive and 5 Gram-negative bacteria. <b>Results</b>: Among the patients, 11 girls presented with acute lymphoblastic leukemia (ALL) type B, while one boy and one girl had acute myeloid leukemia, and, as for boys, three had ALL type T and two had pre-B ALL. The most common pathogens were methicillin-resistant <i>Staphylococcus aureus</i> (MRSA, 11 patients), methicillin-sensitive <i>Staphylococcus aureus</i> (MSSA, 6 patients), <i>Klebsiella</i> spp., and <i>Staphylococcus epidermidis</i>. Due to the patients’ compromised health, most required intensive care and strong antibiotic regimens, including linezolid, vancomycin, and ertapenem, which showed limited resistance. <b>Conclusions</b>: These findings highlight the critical importance of understanding bacterial resistance patterns to guide effective treatments in vulnerable populations. Knowing specific resistance profiles can be lifesaving, allowing for tailored therapies that improve survival rates in children with leukemia facing serious bacterial infections. Focusing on the dual aspects of pediatric patients and multidrug-resistant bacterial infections, this study aims to highlight the importance of addressing these factors together to enhance therapeutic approaches in vulnerable populations.https://www.mdpi.com/2079-6382/13/12/1234pediatric leukemiaantibiotic resistancemultidrug-resistant infectionsimmunocompromised patientsinfection managementantimicrobial susceptibility |
| spellingShingle | Cristina Elena Singer Alin Iulian Silviu Popescu Renata Maria Văruț Mihaela Popescu Dira Loredana Kristina Radivojevic Petrescu Ileana Octavia Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children Antibiotics pediatric leukemia antibiotic resistance multidrug-resistant infections immunocompromised patients infection management antimicrobial susceptibility |
| title | Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children |
| title_full | Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children |
| title_fullStr | Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children |
| title_full_unstemmed | Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children |
| title_short | Bacterial Pathogen Profiles and Antibiotic Resistance in Pediatric Leukemia Patients: Insights for Optimizing Infection Management in Immunocompromised Children |
| title_sort | bacterial pathogen profiles and antibiotic resistance in pediatric leukemia patients insights for optimizing infection management in immunocompromised children |
| topic | pediatric leukemia antibiotic resistance multidrug-resistant infections immunocompromised patients infection management antimicrobial susceptibility |
| url | https://www.mdpi.com/2079-6382/13/12/1234 |
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