Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities
Novel natural nanomaterials are extensively investigated nowadays due to their potential biological activities and low toxicity. In the present investigation, polyvinyl alcohol was used as a green reducing agent to synthesize Plumeria rubra nanoparticles. Plumeria rubra flowers were collected and ex...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004244 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573053751525376 |
|---|---|
| author | Bassma H. Elwakil Mohab H. Elsabrouty Areej Eskandrani Keshav Raj Paudel Esraa Abdelhamid Moneer |
| author_facet | Bassma H. Elwakil Mohab H. Elsabrouty Areej Eskandrani Keshav Raj Paudel Esraa Abdelhamid Moneer |
| author_sort | Bassma H. Elwakil |
| collection | DOAJ |
| description | Novel natural nanomaterials are extensively investigated nowadays due to their potential biological activities and low toxicity. In the present investigation, polyvinyl alcohol was used as a green reducing agent to synthesize Plumeria rubra nanoparticles. Plumeria rubra flowers were collected and extracted using a Soxhlet apparatus and examined through gas and liquid chromatography which revealed the presence of palmitic acid, linoleic acid, N-(O-Nitrophenylthio)-l-leucine, plumieridin B, lupeol, and rutin. The antimicrobial activity of the flower extract showed MIC values between 15.6 and 250.0 μg/mL. The optimum conditions for Plumeria rubra nanoparticle synthesis were 30 min stirring time and a 1:1 PVA/Plumeria rubra ratio. The optimized nanoparticles showed antimicrobial activity reached 7.8 μg/mL with entrapment and loading efficiencies %, zeta size, zeta potential, and PDI were 89.0 %, 40.0 %, 18.5 nm, −1.65 mV, and 0.29, respectively. The cytotoxic effect (IC50) of Plumeria rubra nanoparticles reached 503.2 μg/mL. Plumeria rubra nanoparticles showed low antiviral activity against 229E (low-pathogenic coronavirus), with selectivity index 2.90. Moreover, the synthesized Plumeria rubra nanoparticles' anti-inflammatory effect showed effective and selective COX-2 inhibition (IC50 = 4.2 μM, SI = 15.57). On top of that, the synthesized nanoparticles reduced the parasitic tachyzoites’ count by 37, 43, and 49 % in the spleen, brain, and liver, respectively. |
| format | Article |
| id | doaj-art-0ad07b81c43242f5a1edd84018fdba40 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-0ad07b81c43242f5a1edd84018fdba402025-02-02T05:28:52ZengElsevierHeliyon2405-84402025-01-01112e42044Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activitiesBassma H. Elwakil0Mohab H. Elsabrouty1Areej Eskandrani2Keshav Raj Paudel3Esraa Abdelhamid Moneer4Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, Egypt; Corresponding author.Department of Botany & Microbiology, Faculty of Science, Alexandria University, Alexandria, 21544, EgyptDepartment of Chemistry, College of Science, Taibah University, Madinah, 30002, Kingdom of Saudi ArabiaCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and the University of Technology Sydney, Sydney, NSW, Australia; Corresponding author.Department of Medical Laboratory Technology, Faculty of Applied Health Sciences Technology, Pharos University in Alexandria, Alexandria, 21526, EgyptNovel natural nanomaterials are extensively investigated nowadays due to their potential biological activities and low toxicity. In the present investigation, polyvinyl alcohol was used as a green reducing agent to synthesize Plumeria rubra nanoparticles. Plumeria rubra flowers were collected and extracted using a Soxhlet apparatus and examined through gas and liquid chromatography which revealed the presence of palmitic acid, linoleic acid, N-(O-Nitrophenylthio)-l-leucine, plumieridin B, lupeol, and rutin. The antimicrobial activity of the flower extract showed MIC values between 15.6 and 250.0 μg/mL. The optimum conditions for Plumeria rubra nanoparticle synthesis were 30 min stirring time and a 1:1 PVA/Plumeria rubra ratio. The optimized nanoparticles showed antimicrobial activity reached 7.8 μg/mL with entrapment and loading efficiencies %, zeta size, zeta potential, and PDI were 89.0 %, 40.0 %, 18.5 nm, −1.65 mV, and 0.29, respectively. The cytotoxic effect (IC50) of Plumeria rubra nanoparticles reached 503.2 μg/mL. Plumeria rubra nanoparticles showed low antiviral activity against 229E (low-pathogenic coronavirus), with selectivity index 2.90. Moreover, the synthesized Plumeria rubra nanoparticles' anti-inflammatory effect showed effective and selective COX-2 inhibition (IC50 = 4.2 μM, SI = 15.57). On top of that, the synthesized nanoparticles reduced the parasitic tachyzoites’ count by 37, 43, and 49 % in the spleen, brain, and liver, respectively.http://www.sciencedirect.com/science/article/pii/S2405844025004244Plumeria rubra extractPlumeria rubra/PVA nanoparticlesBiological activityToxoplasma gondiiLow pathogenic corona virusCytotoxicity |
| spellingShingle | Bassma H. Elwakil Mohab H. Elsabrouty Areej Eskandrani Keshav Raj Paudel Esraa Abdelhamid Moneer Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities Heliyon Plumeria rubra extract Plumeria rubra/PVA nanoparticles Biological activity Toxoplasma gondii Low pathogenic corona virus Cytotoxicity |
| title | Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities |
| title_full | Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities |
| title_fullStr | Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities |
| title_full_unstemmed | Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities |
| title_short | Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities |
| title_sort | multifunctional plumeria rubra nanoparticles antimicrobial antiviral antiparasitic and anti inflammatory activities |
| topic | Plumeria rubra extract Plumeria rubra/PVA nanoparticles Biological activity Toxoplasma gondii Low pathogenic corona virus Cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004244 |
| work_keys_str_mv | AT bassmahelwakil multifunctionalplumeriarubrananoparticlesantimicrobialantiviralantiparasiticandantiinflammatoryactivities AT mohabhelsabrouty multifunctionalplumeriarubrananoparticlesantimicrobialantiviralantiparasiticandantiinflammatoryactivities AT areejeskandrani multifunctionalplumeriarubrananoparticlesantimicrobialantiviralantiparasiticandantiinflammatoryactivities AT keshavrajpaudel multifunctionalplumeriarubrananoparticlesantimicrobialantiviralantiparasiticandantiinflammatoryactivities AT esraaabdelhamidmoneer multifunctionalplumeriarubrananoparticlesantimicrobialantiviralantiparasiticandantiinflammatoryactivities |