A novel pseudotype derived of the canine distemper virus for adapter-mediated lentiviral transduction in vivo

A novel pseudotype derived of the canine distemper virus for adapter-mediated lentiviral transduction in vivo

Targeted cell entry with lentiviral vectors (LVs) is one approach to enable efficient and specific gene delivery in the context of immunotherapies, such as chimeric antigen receptor (CAR)-T cell therapy. We have recently shown the generation of CAR-T products with varying CD4:CD8 ratios with our sel...

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Bibliographic Details
Main Authors: Nora Winter, Carolin Kolbe, Shima Ferdos, Larissa Steiner, Nils Bartelsen, Dominik Lock, Fabian Engert, Boris Engels, Mario Assenmacher, Michael Schindler, Ulrich M. Lauer, Thomas Schaser, Nicole Cordes
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vectors
pseudotype
canine distemper virus
Adapter-LV
gene therapy
CAR T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001214
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