The effect of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in testicular tissues of diabetic rats with acute morphine withdrawal syndrome
Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of dia...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Kashan University of Medical Sciences
2024-04-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
| Subjects: | |
| Online Access: | http://feyz.kaums.ac.ir/article-1-5009-en.pdf |
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| Summary: | Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome.
Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study.
Results: The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001).
Conclusion: Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats. |
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| ISSN: | 3060-5806 3060-5814 |