A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 (KCNB1) or Kv2.2 (KCNB2). Mammals have 10 KvS subunits: Kv5.1 (KCNF1), Kv6.1 (KCNG1), Kv6.2 (KCNG2), Kv6.3 (KCNG3), Kv6.4 (KCNG4), Kv8.1 (KCNV1), Kv8.2 (KCNV2), Kv9.1 (KC...

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Bibliographic Details
Main Authors:	Robert G Stewart, Matthew James Marquis, Sooyeon Jo, Brandon J Harris, Aman S Aberra, Verity Cook, Zachary Whiddon, Vladimir Yarov-Yarovoy, Michael Ferns, Jon T Sack
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-05-01
Series:	eLife
Subjects:	voltage-gated potassium channel RY785 guangxitoxin-1E (GxTX) chinese hamster ovary (CHO) cells mouse neurons human neurons
Online Access:	https://elifesciences.org/articles/99410
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A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

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