Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China
Background and objectiveIncreased nuchal translucency (NT) thickness measured at 11–14 weeks of gestation in fetuses has been linked to adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in fetuses with NT ≥3.0 mm.MethodsThis retrospective analysis included 4,200 singleton p...
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Frontiers Media S.A.
2025-04-01
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| author | Zhenglong Guo Wenke Yang Qiongrui Zhao Yuwei Zhang Xin Wang Jinming Wang Ruili Wang Ruili Wang Bingtao Hao Shixiu Liao |
| author_facet | Zhenglong Guo Wenke Yang Qiongrui Zhao Yuwei Zhang Xin Wang Jinming Wang Ruili Wang Ruili Wang Bingtao Hao Shixiu Liao |
| author_sort | Zhenglong Guo |
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| description | Background and objectiveIncreased nuchal translucency (NT) thickness measured at 11–14 weeks of gestation in fetuses has been linked to adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in fetuses with NT ≥3.0 mm.MethodsThis retrospective analysis included 4,200 singleton pregnancies diagnosed with increased NT thickness (≥3.0 mm) through first-trimester ultrasound screening across 76 hospitals in Henan Province from 2017 to 2021. Follow-up on pregnancy outcomes was completed through telephone interviews and electronic medical records.ResultsAmong the 4,200 pregnancies with NT ≥3.0 mm, adverse pregnancy outcomes were observed in 31.5% of the fetuses. These outcomes included elective termination of pregnancy (TOP), spontaneous abortion (SA), threatened abortion (TA), and live birth with malformations. A total of 547 fetuses underwent further examination through karyotype analysis after genetic counseling, revealing that 10.2% were aneuploid, primarily due to Trisomy 21 (7.1%).ConclusionThe incidence of increased NT in our study was 0.49%, which was associated with chromosomal abnormalities and developmental disorders, leading to an increased risk of adverse pregnancy outcomes. Abnormal ultrasound soft markers, along with NT > 4 mm, may further elevate the risk of adverse pregnancy outcomes. These findings should be taken seriously in the context of further prenatal diagnosis for fetuses with increased NT. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-0a976da5ae1f4bb5b6642e16cfa659db2025-08-20T02:18:59ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15145041514504Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, ChinaZhenglong Guo0Wenke Yang1Qiongrui Zhao2Yuwei Zhang3Xin Wang4Jinming Wang5Ruili Wang6Ruili Wang7Bingtao Hao8Shixiu Liao9Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Ultrasound, Henan Provincial People’s Hospital, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Provincial Key Laboratory of Genetic Diseases and Functional Genomics & National Health Commission Key Laboratory of Birth Defects Prevention, Medical Genetics Institute of Henan Province, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, ChinaBackground and objectiveIncreased nuchal translucency (NT) thickness measured at 11–14 weeks of gestation in fetuses has been linked to adverse pregnancy outcomes. This study aimed to evaluate pregnancy outcomes in fetuses with NT ≥3.0 mm.MethodsThis retrospective analysis included 4,200 singleton pregnancies diagnosed with increased NT thickness (≥3.0 mm) through first-trimester ultrasound screening across 76 hospitals in Henan Province from 2017 to 2021. Follow-up on pregnancy outcomes was completed through telephone interviews and electronic medical records.ResultsAmong the 4,200 pregnancies with NT ≥3.0 mm, adverse pregnancy outcomes were observed in 31.5% of the fetuses. These outcomes included elective termination of pregnancy (TOP), spontaneous abortion (SA), threatened abortion (TA), and live birth with malformations. A total of 547 fetuses underwent further examination through karyotype analysis after genetic counseling, revealing that 10.2% were aneuploid, primarily due to Trisomy 21 (7.1%).ConclusionThe incidence of increased NT in our study was 0.49%, which was associated with chromosomal abnormalities and developmental disorders, leading to an increased risk of adverse pregnancy outcomes. Abnormal ultrasound soft markers, along with NT > 4 mm, may further elevate the risk of adverse pregnancy outcomes. These findings should be taken seriously in the context of further prenatal diagnosis for fetuses with increased NT.https://www.frontiersin.org/articles/10.3389/fmed.2025.1514504/fullnuchal translucency thicknesspregnancy outcomefirst-trimester screeningchromosome abnormalitiesultrasound soft indicators |
| spellingShingle | Zhenglong Guo Wenke Yang Qiongrui Zhao Yuwei Zhang Xin Wang Jinming Wang Ruili Wang Ruili Wang Bingtao Hao Shixiu Liao Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China Frontiers in Medicine nuchal translucency thickness pregnancy outcome first-trimester screening chromosome abnormalities ultrasound soft indicators |
| title | Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China |
| title_full | Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China |
| title_fullStr | Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China |
| title_full_unstemmed | Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China |
| title_short | Pregnancy outcomes of 4,200 fetuses with increased nuchal translucency in Henan, China |
| title_sort | pregnancy outcomes of 4 200 fetuses with increased nuchal translucency in henan china |
| topic | nuchal translucency thickness pregnancy outcome first-trimester screening chromosome abnormalities ultrasound soft indicators |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1514504/full |
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