Advances and prospects of cell-penetrating peptides in tumor immunotherapy
Abstract Cell-penetrating peptides (CPPs) have been shown to have superior material transport ability because poor infiltration of activated lymphocytes into tumors is one of the crucial factors limiting the therapeutic effect of tumor immunotherapy. Numerous studies have investigated the potential...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86130-8 |
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| author | Di Yang Baorui Liu Huizi Sha |
| author_facet | Di Yang Baorui Liu Huizi Sha |
| author_sort | Di Yang |
| collection | DOAJ |
| description | Abstract Cell-penetrating peptides (CPPs) have been shown to have superior material transport ability because poor infiltration of activated lymphocytes into tumors is one of the crucial factors limiting the therapeutic effect of tumor immunotherapy. Numerous studies have investigated the potential application of CPPs in tumor immunotherapy. This review delves into the crucial role that CPPs play in enhancing tumor immunotherapy, emphasizing their impact on various immunotherapy strategies, such as cytokine therapy, adoptive cell therapy, cancer vaccines, and immune checkpoint inhibitors. We also discuss the practical application challenges associated with enhancing the efficiency of CPPs in terms of their stability and targeting ability. In conclusion, the combination of CPPs with tumor immunotherapy is a promising strategy that has potential for precision administration and requires further research for optimal implementation. |
| format | Article |
| id | doaj-art-0a942632f9604ce5b3819d373c7c0034 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0a942632f9604ce5b3819d373c7c00342025-02-02T12:21:49ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-025-86130-8Advances and prospects of cell-penetrating peptides in tumor immunotherapyDi Yang0Baorui Liu1Huizi Sha2The Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityThe Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityThe Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University and Clinical Cancer Institute of Nanjing UniversityAbstract Cell-penetrating peptides (CPPs) have been shown to have superior material transport ability because poor infiltration of activated lymphocytes into tumors is one of the crucial factors limiting the therapeutic effect of tumor immunotherapy. Numerous studies have investigated the potential application of CPPs in tumor immunotherapy. This review delves into the crucial role that CPPs play in enhancing tumor immunotherapy, emphasizing their impact on various immunotherapy strategies, such as cytokine therapy, adoptive cell therapy, cancer vaccines, and immune checkpoint inhibitors. We also discuss the practical application challenges associated with enhancing the efficiency of CPPs in terms of their stability and targeting ability. In conclusion, the combination of CPPs with tumor immunotherapy is a promising strategy that has potential for precision administration and requires further research for optimal implementation.https://doi.org/10.1038/s41598-025-86130-8Cell-penetrating peptidesTumor immunotherapyVaccineTumor-targeted peptide |
| spellingShingle | Di Yang Baorui Liu Huizi Sha Advances and prospects of cell-penetrating peptides in tumor immunotherapy Scientific Reports Cell-penetrating peptides Tumor immunotherapy Vaccine Tumor-targeted peptide |
| title | Advances and prospects of cell-penetrating peptides in tumor immunotherapy |
| title_full | Advances and prospects of cell-penetrating peptides in tumor immunotherapy |
| title_fullStr | Advances and prospects of cell-penetrating peptides in tumor immunotherapy |
| title_full_unstemmed | Advances and prospects of cell-penetrating peptides in tumor immunotherapy |
| title_short | Advances and prospects of cell-penetrating peptides in tumor immunotherapy |
| title_sort | advances and prospects of cell penetrating peptides in tumor immunotherapy |
| topic | Cell-penetrating peptides Tumor immunotherapy Vaccine Tumor-targeted peptide |
| url | https://doi.org/10.1038/s41598-025-86130-8 |
| work_keys_str_mv | AT diyang advancesandprospectsofcellpenetratingpeptidesintumorimmunotherapy AT baoruiliu advancesandprospectsofcellpenetratingpeptidesintumorimmunotherapy AT huizisha advancesandprospectsofcellpenetratingpeptidesintumorimmunotherapy |