Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma

Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma

Lung cancer (LC) and breast cancer (BC) are two common malignant tumors with the highest incidence rate in men and women worldwide, respectively. As the treatment effect of currently available therapies for LC and BC is unsatisfying, searching for new therapeutic drugs has become an urgent need to b...

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Bibliographic Details
Main Authors: Jinxia Cheng, Ying Chen, Qi Chen, Ning Cao, Chuyu He, Yanjun Xu, Xiaoying Zhang, Qiang Li, Hong Hong, Jianwei Jiang, Yuechun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
EM-2
autophagy
ER stress
cell cycle
apoptosis
lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1580217/full
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