Terapeutic hypothermia in neuroprotection has an impact on neuroplasticity in brain ischemia and trauma
Background. Thermoregulation maintains a stable body temperature, which is essential for normal physiological function. Therapeutic hypothermia is effectively used for neuroprotection in stroke, traumatic brain injury, increased intracranial pressure, and other conditions. Brain cooling reduces cell...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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V. N. Karazin Kharkiv National University
2025-02-01
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| Series: | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| Subjects: | |
| Online Access: | https://ukrmedsci.com/index.php/visnyk/article/view/146 |
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| Summary: | Background. Thermoregulation maintains a stable body temperature, which is essential for normal physiological function. Therapeutic hypothermia is effectively used for neuroprotection in stroke, traumatic brain injury, increased intracranial pressure, and other conditions. Brain cooling reduces cellular damage, limits necrosis, and improves brain function. The optimal timing and duration of therapy depend on the specific condition. Hypothermia has significant potential when combined with other treatment methods, particularly pharmacological strategies, to enhance neuroprotection outcomes.
Purpose – to characterize the current understanding of the role of therapeutic hypothermia in neuroprotection in traumatic brain injury and ischemic stroke.
Materials and Methods. The selection of publications was carried out using databases such as PubMed, Clinical Key, Cochrane Library, eBook Business Collection, and Google Scholar with keywords including hypothermia, neuroprotection, traumatic brain injury, ischemic stroke, among others. The literature search was conducted in three stages: first, identifying relevant publications; second, reviewing article abstracts; and third, analyzing full-text articles for inclusion criteria. Inclusion criteria comprised topic relevance, adherence to evidence-based medicine, and access to full-text articles. The review was prepared in accordance with PRISMA guidelines.
Results. Selective brain cooling, applied for neuroprotection, holds significant potential in reducing neuronal damage in ischemic stroke and traumatic brain injury. This method decreases neuronal metabolic activity, enhances their survival under restricted blood supply, and reduces damage from oxidative stress and neurotoxicity. The use of transarterial cooling enables targeted brain cooling, effectively lowering temperature in affected regions without impairing the function of other organs. However, further clinical research is necessary to optimize therapeutic approaches and determine the most effective treatment protocols, ensuring long-term efficacy and safety.
Conclusions. Therapeutic hypothermia, particularly selective brain cooling, reduces the metabolic demands of brain cells, mitigating ischemic and traumatic damage by decreasing oxidative stress, excitotoxicity, and inflammation. This method effectively reduces neuronal injury in ischemic stroke by limiting inflammation and oxidative stress; however, further studies are needed to refine optimal treatment conditions. Hypothermia may also support neuroplasticity in traumatic brain injuries, yet additional research is required to evaluate its full effectiveness.
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| ISSN: | 2313-6693 2313-2396 |