Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects

Verbascoside is a polyphenolic compound that belongs to the phenylethanoid glucosides. It occurs in more than 220 plant species. The species with high content of this compound are used in folk medicine, and in modern phytotherapy, mostly based on its recognized anti-inflammatory and antimicrobial ef...

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Main Authors: Mirjana Marčetić, Biljana Bufan, Milica Drobac, Jelena Antić Stanković, Nevena Arsenović Ranin, Marina T. Milenković, Dragana D. Božić
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/14/7/697
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author Mirjana Marčetić
Biljana Bufan
Milica Drobac
Jelena Antić Stanković
Nevena Arsenović Ranin
Marina T. Milenković
Dragana D. Božić
author_facet Mirjana Marčetić
Biljana Bufan
Milica Drobac
Jelena Antić Stanković
Nevena Arsenović Ranin
Marina T. Milenković
Dragana D. Božić
author_sort Mirjana Marčetić
collection DOAJ
description Verbascoside is a polyphenolic compound that belongs to the phenylethanoid glucosides. It occurs in more than 220 plant species. The species with high content of this compound are used in folk medicine, and in modern phytotherapy, mostly based on its recognized anti-inflammatory and antimicrobial effects. Studies conducted so far confirmed these effects, and also pointed to others (i.e., anti-cancer, neuro-, cardio-, hepato-, and nephro-protective). This review presents data on the chemistry, occurrence, and biosynthesis of verbascoside. Additionally, it focuses on the cytotoxic, antimicrobial, anti-inflammatory, and immunomodulatory effects, as well as the main cellular and molecular mechanisms of its action.
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publishDate 2025-07-01
publisher MDPI AG
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series Antibiotics
spelling doaj-art-0a768085ecf047a2971d73f9dbfd33f92025-08-20T02:45:48ZengMDPI AGAntibiotics2079-63822025-07-0114769710.3390/antibiotics14070697Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory EffectsMirjana Marčetić0Biljana Bufan1Milica Drobac2Jelena Antić Stanković3Nevena Arsenović Ranin4Marina T. Milenković5Dragana D. Božić6Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaVerbascoside is a polyphenolic compound that belongs to the phenylethanoid glucosides. It occurs in more than 220 plant species. The species with high content of this compound are used in folk medicine, and in modern phytotherapy, mostly based on its recognized anti-inflammatory and antimicrobial effects. Studies conducted so far confirmed these effects, and also pointed to others (i.e., anti-cancer, neuro-, cardio-, hepato-, and nephro-protective). This review presents data on the chemistry, occurrence, and biosynthesis of verbascoside. Additionally, it focuses on the cytotoxic, antimicrobial, anti-inflammatory, and immunomodulatory effects, as well as the main cellular and molecular mechanisms of its action.https://www.mdpi.com/2079-6382/14/7/697verbascosideacteosidecytotoxicityantimicrobial effectanti-inflammatory effectimmunomodulatory effect
spellingShingle Mirjana Marčetić
Biljana Bufan
Milica Drobac
Jelena Antić Stanković
Nevena Arsenović Ranin
Marina T. Milenković
Dragana D. Božić
Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
Antibiotics
verbascoside
acteoside
cytotoxicity
antimicrobial effect
anti-inflammatory effect
immunomodulatory effect
title Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
title_full Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
title_fullStr Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
title_full_unstemmed Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
title_short Multifaceted Biological Properties of Verbascoside/Acteoside: Antimicrobial, Cytotoxic, Anti-Inflammatory, and Immunomodulatory Effects
title_sort multifaceted biological properties of verbascoside acteoside antimicrobial cytotoxic anti inflammatory and immunomodulatory effects
topic verbascoside
acteoside
cytotoxicity
antimicrobial effect
anti-inflammatory effect
immunomodulatory effect
url https://www.mdpi.com/2079-6382/14/7/697
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