Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits
Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sono...
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/504248 |
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| author | Konstantinos Kasapas Angela Diamantopoulou Nicolaos Pentilas Apostolos Papalois Emmanuel Douzinas Gregorios Kouraklis Michel Slama Abdullah Sulieman Terkawi Michael Blaivas Ashot Ernest Sargsyan Dimitrios Karakitsos |
| author_facet | Konstantinos Kasapas Angela Diamantopoulou Nicolaos Pentilas Apostolos Papalois Emmanuel Douzinas Gregorios Kouraklis Michel Slama Abdullah Sulieman Terkawi Michael Blaivas Ashot Ernest Sargsyan Dimitrios Karakitsos |
| author_sort | Konstantinos Kasapas |
| collection | DOAJ |
| description | Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) measurements. Material and Methods. Twenty rabbits participated in the study. An intraparenchymal ICP catheter and a 5F Swan-Ganz catheter (SG) for the hematoma reproduction were used. We successively introduced 0.1 mL increments of autologous blood into the SG until the Cushing reaction occurred. Synchronous ICP and ultrasound measurements were performed accordingly. Results. A constant increase of PI and ONSD and a decrease of V values were observed with increased ICP values. The relationship between the ultrasound variables and ICP was exponential; thus curved prediction equations of ICP were used. PI, ONSD, and V were significantly correlated with ICP (r2=0.84±0.076, r2=0.62±0.119, and r2=0.78±0.09, resp. (all P<0.001)). Conclusion. Although statistically significant prediction models of ICP were derived from ultrasound indices, the exponential relationship between the parameters underpins that results should be interpreted with caution and in the current experimental context. |
| format | Article |
| id | doaj-art-0a761a78c9d149d79465c27d5541d230 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0a761a78c9d149d79465c27d5541d2302025-02-03T05:43:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/504248504248Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on RabbitsKonstantinos Kasapas0Angela Diamantopoulou1Nicolaos Pentilas2Apostolos Papalois3Emmanuel Douzinas4Gregorios Kouraklis5Michel Slama6Abdullah Sulieman Terkawi7Michael Blaivas8Ashot Ernest Sargsyan9Dimitrios Karakitsos10Department of Neurosurgery, Athens General Hospital “G. Gennimatas”, 11527 Athens, Greece2nd Department of Surgery, Athens Medical School, Laiko University Hospital, 11527 Athens, GreeceIntensive Care Unit, Athens General Hospital “G. Gennimatas”, Athens, GreeceExperimental Research Center ELPEN, 19009 Athens, Greece3rd ICU Department, Athens Medical School, Evgenideio University Hospital, 15128 Athens, Greece2nd Department of Surgery, Athens Medical School, Laiko University Hospital, 11527 Athens, GreeceICU, Amiens University Hospital, 80054 Amiens, FranceDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22903, USADepartment of Internal Medicine, School of Medicine, University of South Carolina, Columbia, SC 29225, USAWyle Science, Technology & Engineering Group/NASA Bioastronautics, Houston, TX 77058, USADepartment of Internal Medicine, School of Medicine, University of South Carolina, Columbia, SC 29225, USAIntroduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) measurements. Material and Methods. Twenty rabbits participated in the study. An intraparenchymal ICP catheter and a 5F Swan-Ganz catheter (SG) for the hematoma reproduction were used. We successively introduced 0.1 mL increments of autologous blood into the SG until the Cushing reaction occurred. Synchronous ICP and ultrasound measurements were performed accordingly. Results. A constant increase of PI and ONSD and a decrease of V values were observed with increased ICP values. The relationship between the ultrasound variables and ICP was exponential; thus curved prediction equations of ICP were used. PI, ONSD, and V were significantly correlated with ICP (r2=0.84±0.076, r2=0.62±0.119, and r2=0.78±0.09, resp. (all P<0.001)). Conclusion. Although statistically significant prediction models of ICP were derived from ultrasound indices, the exponential relationship between the parameters underpins that results should be interpreted with caution and in the current experimental context.http://dx.doi.org/10.1155/2014/504248 |
| spellingShingle | Konstantinos Kasapas Angela Diamantopoulou Nicolaos Pentilas Apostolos Papalois Emmanuel Douzinas Gregorios Kouraklis Michel Slama Abdullah Sulieman Terkawi Michael Blaivas Ashot Ernest Sargsyan Dimitrios Karakitsos Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits The Scientific World Journal |
| title | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
| title_full | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
| title_fullStr | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
| title_full_unstemmed | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
| title_short | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
| title_sort | invasive and ultrasound based monitoring of the intracranial pressure in an experimental model of epidural hematoma progressing towards brain tamponade on rabbits |
| url | http://dx.doi.org/10.1155/2014/504248 |
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