Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography
<b>Background/Objectives</b>: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value of CTRP5 and chemerin in differentiating coronary computed tomography angiography (CCTA)-con...
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MDPI AG
2025-01-01
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| author | Taha Okan Cihan Altın Caner Topaloglu Mehmet Doruk Mehmet Birhan Yılmaz |
| author_facet | Taha Okan Cihan Altın Caner Topaloglu Mehmet Doruk Mehmet Birhan Yılmaz |
| author_sort | Taha Okan |
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| description | <b>Background/Objectives</b>: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value of CTRP5 and chemerin in differentiating coronary computed tomography angiography (CCTA)-confirmed coronary artery disease (CAD) versus non-CAD. Secondarily, within the CCTA-confirmed CAD group, the aim was to investigate the relationship between the severity and extent of CAD, as determined by coronary artery calcium score (CACS), and the levels of CTRP5 and chemerin. <b>Methods</b>: Consecutive individuals with chest pain underwent CCTA to evaluate coronary artery anatomy and were divided into two groups. The CCTA-confirmed CAD group included patients with any atherosclerotic plaque (soft, mixed, or calcified) regardless of calcification, while the non-CAD group consisted of individuals without plaques on CCTA, with zero CACS, and without ischemia on stress ECG. Secondarily, in the CCTA-confirmed CAD group, the severity and extent of CAD were evaluated using CACS. Blood samples were collected and stored at −80 °C for analysis of CTRP5 and chemerin levels via ELISA. <b>Results</b>: Serum CTRP5 and chemerin levels were significantly higher in the CAD group compared to the non-CAD group (221.83 ± 103.81 vs. 149.35 ± 50.99 ng/mL, <i>p</i> = 0.003 and 105.02 ± 35.62 vs. 86.07 ± 19.47 ng/mL, <i>p</i> = 0.005, respectively). Receiver operating characteristic (ROC) analysis showed that a CTRP5 cutoff of 172.30 ng/mL had 70% sensitivity and 73% specificity for identifying CAD, while a chemerin cutoff of 90.46 ng/mL had 61% sensitivity and 62% specificity. A strong positive correlation was observed between CTRP5 and chemerin, but neither adipokine showed a correlation with the Agatston score, a measure of CAD severity and extent, nor with coronary artery stenosis as determined by CCTA. <b>Conclusions</b>: CTRP5 and chemerin were significantly elevated in the CCTA-confirmed CAD group compared to the non-CAD group, with CTRP5 showing greater sensitivity and specificity. However, neither adipokine was linked to CAD severity and extent, differing from findings based on invasive coronary angiography (ICA). CTRP5 may serve as a promising “all-or-none biomarker” for CAD presence. |
| format | Article |
| id | doaj-art-0a6e94174ce04ac8a8bd994525734682 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-0a6e94174ce04ac8a8bd9945257346822025-01-24T13:29:06ZengMDPI AGDiagnostics2075-44182025-01-0115220610.3390/diagnostics15020206Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography AngiographyTaha Okan0Cihan Altın1Caner Topaloglu2Mehmet Doruk3Mehmet Birhan Yılmaz4Cardiology Department, Kardiya Medical Center, 35550 Izmir, TurkeyCardiology Department, Faculty of Medicine, Izmir Economy University, 35550 Izmir, TurkeyCardiology Department, Faculty of Medicine, Izmir Economy University, 35550 Izmir, TurkeyIzmir Endocrinology Clinic, 35500 Izmir, TurkeyCardiology Department, Faculty of Medicine, Dokuz Eylul University, 35340 Izmir, Turkey<b>Background/Objectives</b>: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value of CTRP5 and chemerin in differentiating coronary computed tomography angiography (CCTA)-confirmed coronary artery disease (CAD) versus non-CAD. Secondarily, within the CCTA-confirmed CAD group, the aim was to investigate the relationship between the severity and extent of CAD, as determined by coronary artery calcium score (CACS), and the levels of CTRP5 and chemerin. <b>Methods</b>: Consecutive individuals with chest pain underwent CCTA to evaluate coronary artery anatomy and were divided into two groups. The CCTA-confirmed CAD group included patients with any atherosclerotic plaque (soft, mixed, or calcified) regardless of calcification, while the non-CAD group consisted of individuals without plaques on CCTA, with zero CACS, and without ischemia on stress ECG. Secondarily, in the CCTA-confirmed CAD group, the severity and extent of CAD were evaluated using CACS. Blood samples were collected and stored at −80 °C for analysis of CTRP5 and chemerin levels via ELISA. <b>Results</b>: Serum CTRP5 and chemerin levels were significantly higher in the CAD group compared to the non-CAD group (221.83 ± 103.81 vs. 149.35 ± 50.99 ng/mL, <i>p</i> = 0.003 and 105.02 ± 35.62 vs. 86.07 ± 19.47 ng/mL, <i>p</i> = 0.005, respectively). Receiver operating characteristic (ROC) analysis showed that a CTRP5 cutoff of 172.30 ng/mL had 70% sensitivity and 73% specificity for identifying CAD, while a chemerin cutoff of 90.46 ng/mL had 61% sensitivity and 62% specificity. A strong positive correlation was observed between CTRP5 and chemerin, but neither adipokine showed a correlation with the Agatston score, a measure of CAD severity and extent, nor with coronary artery stenosis as determined by CCTA. <b>Conclusions</b>: CTRP5 and chemerin were significantly elevated in the CCTA-confirmed CAD group compared to the non-CAD group, with CTRP5 showing greater sensitivity and specificity. However, neither adipokine was linked to CAD severity and extent, differing from findings based on invasive coronary angiography (ICA). CTRP5 may serve as a promising “all-or-none biomarker” for CAD presence.https://www.mdpi.com/2075-4418/15/2/206CTRP5chemerincoronary artery diseasecoronary computed tomography angiographyAgatston scorecoronary artery calcification |
| spellingShingle | Taha Okan Cihan Altın Caner Topaloglu Mehmet Doruk Mehmet Birhan Yılmaz Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography Diagnostics CTRP5 chemerin coronary artery disease coronary computed tomography angiography Agatston score coronary artery calcification |
| title | Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography |
| title_full | Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography |
| title_fullStr | Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography |
| title_full_unstemmed | Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography |
| title_short | Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography |
| title_sort | diagnostic potential of ctrp5 and chemerin for coronary artery disease a study by coronary computed tomography angiography |
| topic | CTRP5 chemerin coronary artery disease coronary computed tomography angiography Agatston score coronary artery calcification |
| url | https://www.mdpi.com/2075-4418/15/2/206 |
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