The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon)
Type 1 diabetes mellitus (DM) is characterized by irreversible, autoimmune, pancreatic β-cell destruction. During the disease, some patients experience a phase of Partial Clinical Remission (PCR) known as “honeymoon.” This is a transitory period that is characterized by insulin production by residua...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/2630827 |
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| author | Gulsum Ozen Angela Zanfardino Santino Confetto Alessia Piscopo Francesca Casaburo Nadia Tinto Fernanda Iafusco Gulsah Ozen Emanuele Miraglia del Giudice Medine Aysin Tasar Arzu Yilmaz Dario Iafusco |
| author_facet | Gulsum Ozen Angela Zanfardino Santino Confetto Alessia Piscopo Francesca Casaburo Nadia Tinto Fernanda Iafusco Gulsah Ozen Emanuele Miraglia del Giudice Medine Aysin Tasar Arzu Yilmaz Dario Iafusco |
| author_sort | Gulsum Ozen |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (DM) is characterized by irreversible, autoimmune, pancreatic β-cell destruction. During the disease, some patients experience a phase of Partial Clinical Remission (PCR) known as “honeymoon.” This is a transitory period that is characterized by insulin production by residual β cells following DM diagnosis and initiating the insulin therapy. In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience longer Partial Clinical Remission phase. Patients with higher BMI at the diagnosis of DM experienced shorter honeymoon period than the average. Smaller of our patients who diagnosed just DM have more than 297 days honeymoon period with respect to patients with one associated autoimmune disease. This may be due to a continuous and prolonged stimulation of immune system during the period of honeymoon that predispose the patient to develop other TH1 diseases. The patients who experienced more than 297 days Partial Clinical Remission seem under risk of developing one other autoimmune disease more than the patients who experienced less than 297 days Partial Clinical Remission. We have to consider that this observation is very intriguing because many protocols spring-up to try prolonging the honeymoon period in patients with autoimmune DM. If this aim is important from a metabolic point of view, long follow-ups are needed to be sure that the risk of other autoimmune diseases does not increase. |
| format | Article |
| id | doaj-art-0a6b010dedc44bb1bcb925ebbe72c760 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0a6b010dedc44bb1bcb925ebbe72c7602025-02-03T00:58:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/26308272630827The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon)Gulsum Ozen0Angela Zanfardino1Santino Confetto2Alessia Piscopo3Francesca Casaburo4Nadia Tinto5Fernanda Iafusco6Gulsah Ozen7Emanuele Miraglia del Giudice8Medine Aysin Tasar9Arzu Yilmaz10Dario Iafusco11Department of Pediatrics, University of Health Science, Ankara Training and Research Hospital, Ankara, TurkeyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Molecular Medicine and Biotechnology, CEINGE, Naples, ItalyDepartment of Molecular Medicine and Biotechnology, CEINGE, Naples, ItalyFaculty of Medicine, Hacettepe University, Ankara, TurkeyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Pediatrics, University of Health Science, Ankara Training and Research Hospital, Ankara, TurkeyDepartment of Pediatrics, University of Health Science, Ankara Training and Research Hospital, Ankara, TurkeyRegional Centre for Pediatric Diabetes, Department of Pediatrics, University of Campania “Luigi Vanvitelli”, Naples, ItalyType 1 diabetes mellitus (DM) is characterized by irreversible, autoimmune, pancreatic β-cell destruction. During the disease, some patients experience a phase of Partial Clinical Remission (PCR) known as “honeymoon.” This is a transitory period that is characterized by insulin production by residual β cells following DM diagnosis and initiating the insulin therapy. In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience longer Partial Clinical Remission phase. Patients with higher BMI at the diagnosis of DM experienced shorter honeymoon period than the average. Smaller of our patients who diagnosed just DM have more than 297 days honeymoon period with respect to patients with one associated autoimmune disease. This may be due to a continuous and prolonged stimulation of immune system during the period of honeymoon that predispose the patient to develop other TH1 diseases. The patients who experienced more than 297 days Partial Clinical Remission seem under risk of developing one other autoimmune disease more than the patients who experienced less than 297 days Partial Clinical Remission. We have to consider that this observation is very intriguing because many protocols spring-up to try prolonging the honeymoon period in patients with autoimmune DM. If this aim is important from a metabolic point of view, long follow-ups are needed to be sure that the risk of other autoimmune diseases does not increase.http://dx.doi.org/10.1155/2020/2630827 |
| spellingShingle | Gulsum Ozen Angela Zanfardino Santino Confetto Alessia Piscopo Francesca Casaburo Nadia Tinto Fernanda Iafusco Gulsah Ozen Emanuele Miraglia del Giudice Medine Aysin Tasar Arzu Yilmaz Dario Iafusco The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) International Journal of Endocrinology |
| title | The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) |
| title_full | The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) |
| title_fullStr | The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) |
| title_full_unstemmed | The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) |
| title_short | The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) |
| title_sort | association of autoimmune diseases with type 1 diabetes mellitus in children depends also by the length of partial clinical remission phase honeymoon |
| url | http://dx.doi.org/10.1155/2020/2630827 |
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