Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery

Lipid nanoparticles are colloidal carrier systems that have extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical applications. In this work, a cost effective stearic acid-oleic acid nanoparticles (SONs) with high loading of salicylic acid, was prepared by melt emul...

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Main Authors: J. O. Woo, M. Misran, P. F. Lee, L. P. Tan
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2014/205703
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author J. O. Woo
M. Misran
P. F. Lee
L. P. Tan
author_facet J. O. Woo
M. Misran
P. F. Lee
L. P. Tan
author_sort J. O. Woo
collection DOAJ
description Lipid nanoparticles are colloidal carrier systems that have extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical applications. In this work, a cost effective stearic acid-oleic acid nanoparticles (SONs) with high loading of salicylic acid, was prepared by melt emulsification method combined with ultrasonication technique. The physicochemical properties, thermal analysis and encapsulation efficiency of SONs were studied. TEM micrographs revealed that incorporation of oleic acid induces the formation of elongated spherical particles. This observation is in agreement with particle size analysis which also showed that the mean particle size of SONs varied with the amount of OA in the mixture but with no effect on their zeta potential values. Differential scanning calorimetry analysis showed that the SONs prepared in this method have lower crystallinity as compared to pure stearic acid. Different amount of oleic acid incorporated gave different degree of perturbation to the crystalline matrix of SONs and hence resulted in lower degrees of crystallinity, thereby improving their encapsulation efficiencies. The optimized SON was further incorporated in cream and its in vitro release study showed a gradual release for 24 hours, denoting the incorporation of salicylic acid in solid matrix of SON and prolonging the in vitro release.
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publishDate 2014-01-01
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spelling doaj-art-0a6a7bb1729b428696a5f4f14d2fc0cc2025-02-03T07:23:33ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/205703205703Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical DeliveryJ. O. Woo0M. Misran1P. F. Lee2L. P. Tan3Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaMechatronics and BioMedical Engineering, Faculty of Engineering & Science, Universiti Tunku Abdul Rahman, Setapak, 53300 Kuala Lumpur, MalaysiaPrime Oleochemical Industries Sdn. Bhd., Taman Perindustrian Jaya, 47301 Petaling Jaya, Selangor, MalaysiaLipid nanoparticles are colloidal carrier systems that have extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical applications. In this work, a cost effective stearic acid-oleic acid nanoparticles (SONs) with high loading of salicylic acid, was prepared by melt emulsification method combined with ultrasonication technique. The physicochemical properties, thermal analysis and encapsulation efficiency of SONs were studied. TEM micrographs revealed that incorporation of oleic acid induces the formation of elongated spherical particles. This observation is in agreement with particle size analysis which also showed that the mean particle size of SONs varied with the amount of OA in the mixture but with no effect on their zeta potential values. Differential scanning calorimetry analysis showed that the SONs prepared in this method have lower crystallinity as compared to pure stearic acid. Different amount of oleic acid incorporated gave different degree of perturbation to the crystalline matrix of SONs and hence resulted in lower degrees of crystallinity, thereby improving their encapsulation efficiencies. The optimized SON was further incorporated in cream and its in vitro release study showed a gradual release for 24 hours, denoting the incorporation of salicylic acid in solid matrix of SON and prolonging the in vitro release.http://dx.doi.org/10.1155/2014/205703
spellingShingle J. O. Woo
M. Misran
P. F. Lee
L. P. Tan
Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
The Scientific World Journal
title Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
title_full Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
title_fullStr Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
title_full_unstemmed Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
title_short Development of a Controlled Release of Salicylic Acid Loaded Stearic Acid-Oleic Acid Nanoparticles in Cream for Topical Delivery
title_sort development of a controlled release of salicylic acid loaded stearic acid oleic acid nanoparticles in cream for topical delivery
url http://dx.doi.org/10.1155/2014/205703
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AT pflee developmentofacontrolledreleaseofsalicylicacidloadedstearicacidoleicacidnanoparticlesincreamfortopicaldelivery
AT lptan developmentofacontrolledreleaseofsalicylicacidloadedstearicacidoleicacidnanoparticlesincreamfortopicaldelivery