Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks

A 44-year-old-female with angioid streak- (AS-) associated choroidal-neovascularization (CNV) was treated with one dose of intravitreal brolucizumab (IB). At one-month, the patient’s visual acuity (VA) improved from 20/120 to 20/40 with a dry macula on spectral-domain optical-coherence tomography (S...

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Main Authors: Somnath Chakraborty, Jay Umed Sheth
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Ophthalmological Medicine
Online Access:http://dx.doi.org/10.1155/2022/3442306
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author Somnath Chakraborty
Jay Umed Sheth
author_facet Somnath Chakraborty
Jay Umed Sheth
author_sort Somnath Chakraborty
collection DOAJ
description A 44-year-old-female with angioid streak- (AS-) associated choroidal-neovascularization (CNV) was treated with one dose of intravitreal brolucizumab (IB). At one-month, the patient’s visual acuity (VA) improved from 20/120 to 20/40 with a dry macula on spectral-domain optical-coherence tomography (SD-OCT). After observation, the VA improved further to 20/32 with absence of any fluid on the SD-OCT at three months. No ocular or systemic adverse events were noted. In conclusion, intravitreal brolucizumab (IB) is an efficacious and safe therapeutic option for the management of CNV secondary to AS. Further prospective studies with a larger sample size, varied therapeutic regimens, and longer follow-up period are needed to corroborate our findings.
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spelling doaj-art-0a624c39987a4429885eeae26c17618d2025-02-03T01:32:26ZengWileyCase Reports in Ophthalmological Medicine2090-67302022-01-01202210.1155/2022/3442306Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid StreaksSomnath Chakraborty0Jay Umed Sheth1Retina Institute of BengalSurya Eye Institute and Research CenterA 44-year-old-female with angioid streak- (AS-) associated choroidal-neovascularization (CNV) was treated with one dose of intravitreal brolucizumab (IB). At one-month, the patient’s visual acuity (VA) improved from 20/120 to 20/40 with a dry macula on spectral-domain optical-coherence tomography (SD-OCT). After observation, the VA improved further to 20/32 with absence of any fluid on the SD-OCT at three months. No ocular or systemic adverse events were noted. In conclusion, intravitreal brolucizumab (IB) is an efficacious and safe therapeutic option for the management of CNV secondary to AS. Further prospective studies with a larger sample size, varied therapeutic regimens, and longer follow-up period are needed to corroborate our findings.http://dx.doi.org/10.1155/2022/3442306
spellingShingle Somnath Chakraborty
Jay Umed Sheth
Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
Case Reports in Ophthalmological Medicine
title Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
title_full Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
title_fullStr Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
title_full_unstemmed Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
title_short Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks
title_sort intravitreal brolucizumab for choroidal neovascularization associated to angioid streaks
url http://dx.doi.org/10.1155/2022/3442306
work_keys_str_mv AT somnathchakraborty intravitrealbrolucizumabforchoroidalneovascularizationassociatedtoangioidstreaks
AT jayumedsheth intravitrealbrolucizumabforchoroidalneovascularizationassociatedtoangioidstreaks