Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma
Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabet...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1524288/full |
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| Summary: | Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabetic ketoacidosis (DKA). This case report describes a frail elderly patient with high surgical risk diagnosed with pancreatic head insulinoma whose initial treatment with diazoxide was complicated by a hyperglycemic crisis. Her insulinoma was eventually managed with endoscopic ultrasound-guided-radiofrequency ablation (EUS-RFA) with complete resolution of hypoglycemic episodes. This case highlights the importance of monitoring for side effects of diazoxide, especially in the elderly, and the role of EUS-RFA as an emerging non-surgical treatment modality for insulinoma. |
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| ISSN: | 1664-2392 |