The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018
Previous studies have indicated an association between UHR and diabetes risk, but evidence from large-scale and diverse populations remains limited. This study aims to verify UHR’s independent role in diabetes risk prediction in a large sample population and assess its applicability across different...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1499417/full |
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| author | Jianming Yin Chuanjie Zheng Xiaoqian Lin Chaoqiang Huang Zhanhui Hu Shuyuan Lin Yiqian Qu |
| author_facet | Jianming Yin Chuanjie Zheng Xiaoqian Lin Chaoqiang Huang Zhanhui Hu Shuyuan Lin Yiqian Qu |
| author_sort | Jianming Yin |
| collection | DOAJ |
| description | Previous studies have indicated an association between UHR and diabetes risk, but evidence from large-scale and diverse populations remains limited. This study aims to verify UHR’s independent role in diabetes risk prediction in a large sample population and assess its applicability across different populations. We drew upon data from 30,813 participants collected during the 2005–2018 NHANES cycle. The association between UHR and the risk of diabetes was explored using multivariate logistic regression models, with key predictive factors identified through LASSO regression. Model effectiveness was evaluated through receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration metrics. Additionally, restricted cubic spline (RCS) and threshold effect assessments were applied to examine the nonlinear association between UHR and diabetes risk. The results showed that UHR levels were notably elevated in individuals with diabetes when compared to those without diabetes (p < 0.001). The occurrence of diabetes showed a marked increase across ascending UHR quartiles (6.63%, 10.88%, 14.15%, 18.02%; p < 0.001). Results from multivariate logistic regression indicated that elevated UHR was strongly linked to a heightened risk of diabetes; participants in the highest UHR quartile were found to have nearly four times the risk compared to those in the lowest quartile (OR = 4.063, 95% CI: 3.536–4.669, p < 0.001). Subgroup analyses demonstrated that the predictive effect of UHR was more pronounced in females. Key variables selected via LASSO regression improved the model’s performance. Restricted cubic spline (RCS) analysis indicated an inflection point at UHR = 10; beyond this point, diabetes risk accelerated, and when UHR exceeded 18, the risk increased significantly (OR > 1). ROC curve analysis showed the baseline model (M1) had an area under the curve (AUC) of 0.797, while the multivariable model (M4) after LASSO selection had an AUC of 0.789. Decision curve analysis and calibration curves validated the model’s predictive ability and consistency. This study indicates that UHR may be an independent predictor of diabetes risk, showing a positive correlation with diabetes and a more pronounced predictive effect in females. |
| format | Article |
| id | doaj-art-0a1c804a79194e708652db9eb7d82822 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0a1c804a79194e708652db9eb7d828222025-01-23T05:10:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14994171499417The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018Jianming YinChuanjie ZhengXiaoqian LinChaoqiang HuangZhanhui HuShuyuan LinYiqian QuPrevious studies have indicated an association between UHR and diabetes risk, but evidence from large-scale and diverse populations remains limited. This study aims to verify UHR’s independent role in diabetes risk prediction in a large sample population and assess its applicability across different populations. We drew upon data from 30,813 participants collected during the 2005–2018 NHANES cycle. The association between UHR and the risk of diabetes was explored using multivariate logistic regression models, with key predictive factors identified through LASSO regression. Model effectiveness was evaluated through receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration metrics. Additionally, restricted cubic spline (RCS) and threshold effect assessments were applied to examine the nonlinear association between UHR and diabetes risk. The results showed that UHR levels were notably elevated in individuals with diabetes when compared to those without diabetes (p < 0.001). The occurrence of diabetes showed a marked increase across ascending UHR quartiles (6.63%, 10.88%, 14.15%, 18.02%; p < 0.001). Results from multivariate logistic regression indicated that elevated UHR was strongly linked to a heightened risk of diabetes; participants in the highest UHR quartile were found to have nearly four times the risk compared to those in the lowest quartile (OR = 4.063, 95% CI: 3.536–4.669, p < 0.001). Subgroup analyses demonstrated that the predictive effect of UHR was more pronounced in females. Key variables selected via LASSO regression improved the model’s performance. Restricted cubic spline (RCS) analysis indicated an inflection point at UHR = 10; beyond this point, diabetes risk accelerated, and when UHR exceeded 18, the risk increased significantly (OR > 1). ROC curve analysis showed the baseline model (M1) had an area under the curve (AUC) of 0.797, while the multivariable model (M4) after LASSO selection had an AUC of 0.789. Decision curve analysis and calibration curves validated the model’s predictive ability and consistency. This study indicates that UHR may be an independent predictor of diabetes risk, showing a positive correlation with diabetes and a more pronounced predictive effect in females.https://www.frontiersin.org/articles/10.3389/fendo.2024.1499417/fulldiabetesserum uric acidHDL-CUHRNHANES |
| spellingShingle | Jianming Yin Chuanjie Zheng Xiaoqian Lin Chaoqiang Huang Zhanhui Hu Shuyuan Lin Yiqian Qu The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 Frontiers in Endocrinology diabetes serum uric acid HDL-C UHR NHANES |
| title | The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 |
| title_full | The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 |
| title_fullStr | The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 |
| title_full_unstemmed | The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 |
| title_short | The potential of the serum uric acid to high-density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk: a study based on NHANES 2005–2018 |
| title_sort | potential of the serum uric acid to high density lipoprotein cholesterol ratio as a predictive biomarker of diabetes risk a study based on nhanes 2005 2018 |
| topic | diabetes serum uric acid HDL-C UHR NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1499417/full |
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