Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation
Seizures after liver transplantation were previously thought to be a reliable harbinger of catastrophe, but more recent studies have found seizure activity to be relatively common, and most cases do not result in a poor outcome. Generalized seizures are the most common, and they typically occur de n...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/9311922 |
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| author | Brittany Miles Muhammad Mujtaba Shehzad Merwat Rupak Kulkarni Jeffrey Fair Michael Kueht |
| author_facet | Brittany Miles Muhammad Mujtaba Shehzad Merwat Rupak Kulkarni Jeffrey Fair Michael Kueht |
| author_sort | Brittany Miles |
| collection | DOAJ |
| description | Seizures after liver transplantation were previously thought to be a reliable harbinger of catastrophe, but more recent studies have found seizure activity to be relatively common, and most cases do not result in a poor outcome. Generalized seizures are the most common, and they typically occur de novo within the first two weeks after transplantation. The underlying cause for seizure activity in these patients may be complex, with potential etiologies including metabolic, infectious, cerebrovascular, and medication-induced causes. Identification of the underlying cause and the use of antiepileptic drugs (AEDs) is crucial for minimizing risk to the patient’s neurologic and overall health. In this report, we present the case of a patient with refractory seizures unresponsive to conventional treatment, requiring prolonged barbiturate burst suppression with ventilator support. Seizure activity eventually ceased, and the patient made a full recovery. |
| format | Article |
| id | doaj-art-0a14ff1c42844b4f9221920a799c0380 |
| institution | Kabale University |
| issn | 2090-6595 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-0a14ff1c42844b4f9221920a799c03802025-02-03T01:01:29ZengWileyCase Reports in Hepatology2090-65952022-01-01202210.1155/2022/9311922Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver TransplantationBrittany Miles0Muhammad Mujtaba1Shehzad Merwat2Rupak Kulkarni3Jeffrey Fair4Michael Kueht5Department of SurgeryDepartment of Internal MedicineDepartment of Internal MedicineDepartment of SurgeryDepartment of SurgeryDepartment of SurgerySeizures after liver transplantation were previously thought to be a reliable harbinger of catastrophe, but more recent studies have found seizure activity to be relatively common, and most cases do not result in a poor outcome. Generalized seizures are the most common, and they typically occur de novo within the first two weeks after transplantation. The underlying cause for seizure activity in these patients may be complex, with potential etiologies including metabolic, infectious, cerebrovascular, and medication-induced causes. Identification of the underlying cause and the use of antiepileptic drugs (AEDs) is crucial for minimizing risk to the patient’s neurologic and overall health. In this report, we present the case of a patient with refractory seizures unresponsive to conventional treatment, requiring prolonged barbiturate burst suppression with ventilator support. Seizure activity eventually ceased, and the patient made a full recovery.http://dx.doi.org/10.1155/2022/9311922 |
| spellingShingle | Brittany Miles Muhammad Mujtaba Shehzad Merwat Rupak Kulkarni Jeffrey Fair Michael Kueht Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation Case Reports in Hepatology |
| title | Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation |
| title_full | Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation |
| title_fullStr | Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation |
| title_full_unstemmed | Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation |
| title_short | Escalation to Barbiturate-Induced Coma for Refractory Seizures after Liver Transplantation |
| title_sort | escalation to barbiturate induced coma for refractory seizures after liver transplantation |
| url | http://dx.doi.org/10.1155/2022/9311922 |
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