Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies
Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association betwee...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2018/5315098 |
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| author | Yao-Chin Wang Po-An Tai Tahmina Nasrin Poly Md Mohaimenul Islam Hsuan-Chia Yang Chieh-Chen Wu Yu-Chuan (Jack) Li |
| author_facet | Yao-Chin Wang Po-An Tai Tahmina Nasrin Poly Md Mohaimenul Islam Hsuan-Chia Yang Chieh-Chen Wu Yu-Chuan (Jack) Li |
| author_sort | Yao-Chin Wang |
| collection | DOAJ |
| description | Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients. We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk. Data were collected from each study independently, and study duplication was checked by at least three senior researchers based on a standardized protocol. Summary relative risk (RR) with 95% CI was calculated by using a random-effects model. We selected 9 out of 754 unique abstracts for full-text review using our predetermined selection criteria, and 5 out of these 9 studies, comprising 53,955 participants, met all of our inclusion criteria. The overall pooled RR of dementia was 1.75 (95% CI: 1.033–2.964) for SSRIs whereas the overall pooled RR of dementia was 2.131 (95% CI: 1.427–3.184) for tricyclic use. Also, MAOIs showed a high rate of increase with significant heterogeneity. Our findings indicate that antidepressant use is significantly associated with an increased risk of developing dementia. Therefore, we suggest physicians to carefully prescribe antidepressants, especially in elder patients. Additionally, treatment should be stopped if any symptoms related to dementia are to be noticed. |
| format | Article |
| id | doaj-art-0a104a45b3434274846d8c4f9cede0a4 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-0a104a45b3434274846d8c4f9cede0a42025-02-03T01:25:42ZengWileyBehavioural Neurology0953-41801875-85842018-01-01201810.1155/2018/53150985315098Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational StudiesYao-Chin Wang0Po-An Tai1Tahmina Nasrin Poly2Md Mohaimenul Islam3Hsuan-Chia Yang4Chieh-Chen Wu5Yu-Chuan (Jack) Li6Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanDepartment of Surgery, School of Medicine, Buddhist Tzu Chi University, Hualien, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanAntidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients. We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk. Data were collected from each study independently, and study duplication was checked by at least three senior researchers based on a standardized protocol. Summary relative risk (RR) with 95% CI was calculated by using a random-effects model. We selected 9 out of 754 unique abstracts for full-text review using our predetermined selection criteria, and 5 out of these 9 studies, comprising 53,955 participants, met all of our inclusion criteria. The overall pooled RR of dementia was 1.75 (95% CI: 1.033–2.964) for SSRIs whereas the overall pooled RR of dementia was 2.131 (95% CI: 1.427–3.184) for tricyclic use. Also, MAOIs showed a high rate of increase with significant heterogeneity. Our findings indicate that antidepressant use is significantly associated with an increased risk of developing dementia. Therefore, we suggest physicians to carefully prescribe antidepressants, especially in elder patients. Additionally, treatment should be stopped if any symptoms related to dementia are to be noticed.http://dx.doi.org/10.1155/2018/5315098 |
| spellingShingle | Yao-Chin Wang Po-An Tai Tahmina Nasrin Poly Md Mohaimenul Islam Hsuan-Chia Yang Chieh-Chen Wu Yu-Chuan (Jack) Li Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies Behavioural Neurology |
| title | Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies |
| title_full | Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies |
| title_fullStr | Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies |
| title_full_unstemmed | Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies |
| title_short | Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies |
| title_sort | increased risk of dementia in patients with antidepressants a meta analysis of observational studies |
| url | http://dx.doi.org/10.1155/2018/5315098 |
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