Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage
Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) rem...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/2174371 |
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| author | Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Nasir Ahmad Haidari Yu-Chen Chen Xindao Yin |
| author_facet | Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Nasir Ahmad Haidari Yu-Chen Chen Xindao Yin |
| author_sort | Fengfang Li |
| collection | DOAJ |
| description | Objective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients. |
| format | Article |
| id | doaj-art-0a0e0c9863444293bbf69f1964dd954e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0a0e0c9863444293bbf69f1964dd954e2025-02-03T05:57:19ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/21743712174371Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute StageFengfang Li0Liyan Lu1Song’an Shang2Huiyou Chen3Peng Wang4Nasir Ahmad Haidari5Yu-Chen Chen6Xindao Yin7Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaObjective. The influence of cognitive impairment after mild traumatic brain injury (mTBI) on cerebral vascular perfusion has been widely concerned, yet the resting-state cerebral blood flow (CBF) connectivity alterations based on arterial spin labeling (ASL) in mild traumatic brain injury (mTBI) remain unclear. This study investigated region CBF and CBF connectivity features in acute mTBI patients, as well as the associations between CBF changes and cognitive impairment. Materials and Methods. Forty-five acute mTBI patients and 42 health controls underwent pseudocontinuous arterial spin labeling (pCASL) perfusion magnetic resonance imaging (MRI). The alterations in regional CBF and relationship between the CBF changes and cognitive impairment were detected. The ASL-CBF connectivity of the brain regions with regional CBF significant differences was also compared between two groups. Neuropsychological tests covered seven cognitive domains. Associations between the CBF changes and cognitive impairment were further investigated. Results. Compared with the healthy controls, the acute mTBI patients exhibited increased CBF in the bilateral inferior temporal gyrus (ITG) and decreased CBF in the right middle frontal gyrus (MFG), the bilateral superior frontal gyrus (SFG), and the right cerebellum posterior lobe (CPL). In the mTBI patients, significant correlations were identified between the CBF changes and cognitive impairment. Importantly, the acute mTBI patients exhibited CBF disconnections between the right CPL and right fusiform gyrus (FG) as well as bilateral ITG, between the left SFG and left middle occipital gyrus (MOG), and between the right SFG and right FG as well as right parahippocampal gyrus. Conclusion. Our results suggest that acute mTBI patients exhibit both regional CBF abnormalities and CBF connectivity deficits, which may underlie the cognitive impairment of the acute mTBI patients.http://dx.doi.org/10.1155/2020/2174371 |
| spellingShingle | Fengfang Li Liyan Lu Song’an Shang Huiyou Chen Peng Wang Nasir Ahmad Haidari Yu-Chen Chen Xindao Yin Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage Neural Plasticity |
| title | Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage |
| title_full | Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage |
| title_fullStr | Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage |
| title_full_unstemmed | Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage |
| title_short | Cerebral Blood Flow and Its Connectivity Deficits in Mild Traumatic Brain Injury at the Acute Stage |
| title_sort | cerebral blood flow and its connectivity deficits in mild traumatic brain injury at the acute stage |
| url | http://dx.doi.org/10.1155/2020/2174371 |
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