Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway

Nootkatone inhibits the progression of glioblastoma by activating the ATF4-CHOP-CHAC1 pathway

Abstract Glioblastoma multiforme (GBM) represents a primary brain tumor that is widely prevalent, and clinical drugs available for its treatment exhibit varying degrees of resistance. Nootkatone (NKT) is a functional sesquiterpene sourced from traditional Chinese medicine --Alpinia Oxyphylla Miq and...

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Bibliographic Details
Main Authors: Qian Wang, Xiumin Xue, Zhichao Chen, Wei Zhang, Yiming Qian, Danni Chen, Lin Lin, Yinfeng Yuan, Weiqiao Zhao, Zhihui Huang, Yongjie Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
Nootkatone
Glioblastoma multiforme
Proliferation
ROS
ATF4-CHOP-CHAC1
Online Access:https://doi.org/10.1186/s10020-025-01064-1
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