Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications
Diabetes mellitus (DM) is a chronic disease that threatens human health. Although many drugs are available to treat DM, various complications caused by DM are unavoidable. As an emerging treatment for DM, mesenchymal stem cells (MSCs) have shown many advantages and are gradually gaining public atten...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/9324270 |
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| _version_ | 1832547895026384896 |
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| author | Jiarui Zhang Yongqin Zheng Lichenlu Huang Jundong He |
| author_facet | Jiarui Zhang Yongqin Zheng Lichenlu Huang Jundong He |
| author_sort | Jiarui Zhang |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a chronic disease that threatens human health. Although many drugs are available to treat DM, various complications caused by DM are unavoidable. As an emerging treatment for DM, mesenchymal stem cells (MSCs) have shown many advantages and are gradually gaining public attention. This review summarizes the clinical studies on the use of MSCs to treat DM and the potential mechanisms of complications such as pancreatic dysfunction, cardiovascular lesions, renal lesions, neurological lesions, and trauma repair. This review focuses on the research progress on MSC-mediated secretion of cytokines, improvements in the microenvironment, repair of tissue morphology, and related signaling pathways. At present, the sample sizes in clinical studies of MSCs in treating DM are small, and there is a lack of standardized quality control systems in the preparation, transportation, and infusion methods, so we need to conduct more in-depth studies. In conclusion, MSCs have shown superior potential for use in the treatment of DM and its complications and will hopefully become a novel therapeutic approach in the future. |
| format | Article |
| id | doaj-art-0a0d0f71eb60406eb85a21c1c65e8c81 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0a0d0f71eb60406eb85a21c1c65e8c812025-02-03T06:42:50ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/9324270Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its ComplicationsJiarui Zhang0Yongqin Zheng1Lichenlu Huang2Jundong He3Medical SchoolDepartment of Endocrinology and MetabolismMedical SchoolMedical SchoolDiabetes mellitus (DM) is a chronic disease that threatens human health. Although many drugs are available to treat DM, various complications caused by DM are unavoidable. As an emerging treatment for DM, mesenchymal stem cells (MSCs) have shown many advantages and are gradually gaining public attention. This review summarizes the clinical studies on the use of MSCs to treat DM and the potential mechanisms of complications such as pancreatic dysfunction, cardiovascular lesions, renal lesions, neurological lesions, and trauma repair. This review focuses on the research progress on MSC-mediated secretion of cytokines, improvements in the microenvironment, repair of tissue morphology, and related signaling pathways. At present, the sample sizes in clinical studies of MSCs in treating DM are small, and there is a lack of standardized quality control systems in the preparation, transportation, and infusion methods, so we need to conduct more in-depth studies. In conclusion, MSCs have shown superior potential for use in the treatment of DM and its complications and will hopefully become a novel therapeutic approach in the future.http://dx.doi.org/10.1155/2023/9324270 |
| spellingShingle | Jiarui Zhang Yongqin Zheng Lichenlu Huang Jundong He Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications International Journal of Endocrinology |
| title | Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications |
| title_full | Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications |
| title_fullStr | Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications |
| title_full_unstemmed | Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications |
| title_short | Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications |
| title_sort | research progress on mesenchymal stem cells for the treatment of diabetes and its complications |
| url | http://dx.doi.org/10.1155/2023/9324270 |
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