Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few. Increases in mortality and morbidity in obesity relate...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/502749 |
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| author | Shahida A. Khan Ashraf Ali Sarah A. Khan Solafa A. Zahran Ghazi Damanhouri Esam Azhar Ishtiaq Qadri |
| author_facet | Shahida A. Khan Ashraf Ali Sarah A. Khan Solafa A. Zahran Ghazi Damanhouri Esam Azhar Ishtiaq Qadri |
| author_sort | Shahida A. Khan |
| collection | DOAJ |
| description | Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few. Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components. Majorly the thromboxanes, prostaglandins, leukotrienes, lipoxins, and so forth form the group of lipid mediators influencing inflammation. Of special mention are the omega-6 and omega-3 fatty acids that regulate inflammatory mediators of interest in hepatocytes and adipocytes via the cyclooxygenase and lipoxygenase pathways. They also exhibit profound effects on eicosanoid production. The inflammatory cyclooxygenase pathway arising from arachidonic acid is a critical step in the progression of inflammatory responses. New oxygenated products of omega-3 metabolism, namely, resolvins and protectins, behave as endogenous mediators exhibiting powerful anti-inflammatory and immune-regulatory actions via the peroxisome proliferator-activated receptors (PPARs) and G protein coupled receptors (GPCRs). In this review we attempt to discuss the complex pathways and links between obesity and inflammation particularly in relation to different lipid mediators. |
| format | Article |
| id | doaj-art-09fac9f9f0db43268fe500fc0867284d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-09fac9f9f0db43268fe500fc0867284d2025-02-03T06:07:20ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/502749502749Unraveling the Complex Relationship Triad between Lipids, Obesity, and InflammationShahida A. Khan0Ashraf Ali1Sarah A. Khan2Solafa A. Zahran3Ghazi Damanhouri4Esam Azhar5Ishtiaq Qadri6Department of Applied Nutrition, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaDepartment of Medical Biotechnology, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaNational Brain Research Center, Manesar, Gurgaon District, Haryana 122 051, IndiaDepartment of Applied Nutrition, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaKing Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaSpecial Infectious Agents Unit, Biosafety Level 3, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaDepartment of Medical Biotechnology, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi ArabiaObesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few. Increases in mortality and morbidity in obesity related inflammation have initiated studies to explore different lipid mediated molecular pathways of attempting resolution that uncover newer therapeutic opportunities of anti-inflammatory components. Majorly the thromboxanes, prostaglandins, leukotrienes, lipoxins, and so forth form the group of lipid mediators influencing inflammation. Of special mention are the omega-6 and omega-3 fatty acids that regulate inflammatory mediators of interest in hepatocytes and adipocytes via the cyclooxygenase and lipoxygenase pathways. They also exhibit profound effects on eicosanoid production. The inflammatory cyclooxygenase pathway arising from arachidonic acid is a critical step in the progression of inflammatory responses. New oxygenated products of omega-3 metabolism, namely, resolvins and protectins, behave as endogenous mediators exhibiting powerful anti-inflammatory and immune-regulatory actions via the peroxisome proliferator-activated receptors (PPARs) and G protein coupled receptors (GPCRs). In this review we attempt to discuss the complex pathways and links between obesity and inflammation particularly in relation to different lipid mediators.http://dx.doi.org/10.1155/2014/502749 |
| spellingShingle | Shahida A. Khan Ashraf Ali Sarah A. Khan Solafa A. Zahran Ghazi Damanhouri Esam Azhar Ishtiaq Qadri Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation Mediators of Inflammation |
| title | Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation |
| title_full | Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation |
| title_fullStr | Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation |
| title_full_unstemmed | Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation |
| title_short | Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation |
| title_sort | unraveling the complex relationship triad between lipids obesity and inflammation |
| url | http://dx.doi.org/10.1155/2014/502749 |
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