An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias
The differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde am...
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2025-01-01
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| author | Andrew J. Larner |
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| author_sort | Andrew J. Larner |
| collection | DOAJ |
| description | The differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde amnesia with variable retrograde amnesia. Although the clinical phenomenology of TGA is well described, its pathogenesis is not currently understood, thus preventing the development of evidence-based therapeutic recommendations. Here, TGA, TEA, and functional amnesia are considered in light of the historical engram conception of memory, now informed by recent experimental research, as disturbances in distributed ensembles of engram neurones active during memory formation and recall. This analysis affords therapeutic implications for these conditions, should interventions to reactivate latent or silent engrams become available. |
| format | Article |
| id | doaj-art-09f950c29415472580b4864425de4337 |
| institution | Kabale University |
| issn | 2035-8377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Neurology International |
| spelling | doaj-art-09f950c29415472580b4864425de43372025-01-24T13:44:23ZengMDPI AGNeurology International2035-83772025-01-01171810.3390/neurolint17010008An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset AmnesiasAndrew J. Larner0Department of Brain Repair & Rehabilitation, Institute of Neurology, University College London, London WC1E 6BT, UKThe differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde amnesia with variable retrograde amnesia. Although the clinical phenomenology of TGA is well described, its pathogenesis is not currently understood, thus preventing the development of evidence-based therapeutic recommendations. Here, TGA, TEA, and functional amnesia are considered in light of the historical engram conception of memory, now informed by recent experimental research, as disturbances in distributed ensembles of engram neurones active during memory formation and recall. This analysis affords therapeutic implications for these conditions, should interventions to reactivate latent or silent engrams become available.https://www.mdpi.com/2035-8377/17/1/8amnesiaecphoryengramfunctional amnesiaTEATGA |
| spellingShingle | Andrew J. Larner An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias Neurology International amnesia ecphory engram functional amnesia TEA TGA |
| title | An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias |
| title_full | An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias |
| title_fullStr | An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias |
| title_full_unstemmed | An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias |
| title_short | An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias |
| title_sort | engram centric approach to transient global amnesia tga and other acute onset amnesias |
| topic | amnesia ecphory engram functional amnesia TEA TGA |
| url | https://www.mdpi.com/2035-8377/17/1/8 |
| work_keys_str_mv | AT andrewjlarner anengramcentricapproachtotransientglobalamnesiatgaandotheracuteonsetamnesias AT andrewjlarner engramcentricapproachtotransientglobalamnesiatgaandotheracuteonsetamnesias |