Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury
We assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners’ Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estima...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/104282 |
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| author | Sandra Strazzer Maria A. Rocca Erika Molteni Ermelinda De Meo Monica Recla Paola Valsasina Filippo Arrigoni Susanna Galbiati Alessandra Bardoni Massimo Filippi |
| author_facet | Sandra Strazzer Maria A. Rocca Erika Molteni Ermelinda De Meo Monica Recla Paola Valsasina Filippo Arrigoni Susanna Galbiati Alessandra Bardoni Massimo Filippi |
| author_sort | Sandra Strazzer |
| collection | DOAJ |
| description | We assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners’ Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estimated the correlation of such abnormalities with clinical and cognitive deficits. Patients underwent the Wechsler Intelligence Scale for Children (WISC), Wisconsin Card Sorting Test, and Functional Independence Measure (FIM) evaluations. During fMRI, patients and controls activated regions of the attention network. Compared to controls, ABI patients experienced a decreased average fMRI recruitment of the left cerebellum and a decreased deactivation of the left anterior cingulate cortex. With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network. They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT. Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event. Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits. |
| format | Article |
| id | doaj-art-09eda63a323244188a4598e65b0554db |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-09eda63a323244188a4598e65b0554db2025-02-03T06:10:48ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/104282104282Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain InjurySandra Strazzer0Maria A. Rocca1Erika Molteni2Ermelinda De Meo3Monica Recla4Paola Valsasina5Filippo Arrigoni6Susanna Galbiati7Alessandra Bardoni8Massimo Filippi9Acquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyNeuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalyAcquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyNeuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalyAcquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyNeuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalyAcquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyAcquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyAcquired Brain Injury Unit, Scientific Institute “Eugenio Medea”, Via Don Luigi Monza 20, 23842 Bosisio Parini, ItalyNeuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, ItalyWe assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners’ Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estimated the correlation of such abnormalities with clinical and cognitive deficits. Patients underwent the Wechsler Intelligence Scale for Children (WISC), Wisconsin Card Sorting Test, and Functional Independence Measure (FIM) evaluations. During fMRI, patients and controls activated regions of the attention network. Compared to controls, ABI patients experienced a decreased average fMRI recruitment of the left cerebellum and a decreased deactivation of the left anterior cingulate cortex. With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network. They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT. Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event. Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.http://dx.doi.org/10.1155/2015/104282 |
| spellingShingle | Sandra Strazzer Maria A. Rocca Erika Molteni Ermelinda De Meo Monica Recla Paola Valsasina Filippo Arrigoni Susanna Galbiati Alessandra Bardoni Massimo Filippi Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury Neural Plasticity |
| title | Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury |
| title_full | Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury |
| title_fullStr | Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury |
| title_full_unstemmed | Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury |
| title_short | Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury |
| title_sort | altered recruitment of the attention network is associated with disability and cognitive impairment in pediatric patients with acquired brain injury |
| url | http://dx.doi.org/10.1155/2015/104282 |
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