Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients
Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β)...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/385297 |
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| author | Vinod Umare Vandana Pradhan Milind Nadkar Anjali Rajadhyaksha Manisha Patwardhan Kanjaksha K. Ghosh Anita H. Nadkarni |
| author_facet | Vinod Umare Vandana Pradhan Milind Nadkar Anjali Rajadhyaksha Manisha Patwardhan Kanjaksha K. Ghosh Anita H. Nadkarni |
| author_sort | Vinod Umare |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients. One hundred and forty-five healthy controls of the same ethnicity served as a control group. Clinical disease activity was scored according to SLEDAI score. Accordingly, 110 patients had active disease and 35 patients had inactive disease. Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P<0.001). Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P=0.0430) than those of inactive disease patients (43.85±63.36 pg/mL). Mean level of TNF-α was 44.76±68.32 pg/mL for patients with active disease while it was 25.97±22.03 pg/mL for those with inactive disease and this difference was statistically significant (P=0.0161). Similar results were obtained for IL-1β (P=0.0002). Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r=0.20, r=0.27, and r=0.38, resp.). This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease. |
| format | Article |
| id | doaj-art-09e41c777dc94d4882118fe922e677d3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-09e41c777dc94d4882118fe922e677d32025-02-03T01:26:46ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/385297385297Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE PatientsVinod Umare0Vandana Pradhan1Milind Nadkar2Anjali Rajadhyaksha3Manisha Patwardhan4Kanjaksha K. Ghosh5Anita H. Nadkarni6National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, IndiaNational Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, IndiaDepartment of Rheumatology, King Edward Memorial Hospital, Parel, Mumbai, Maharashtra 400012, IndiaDepartment of Rheumatology, King Edward Memorial Hospital, Parel, Mumbai, Maharashtra 400012, IndiaNational Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, IndiaNational Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, IndiaNational Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, Maharashtra 400012, IndiaSystemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients. One hundred and forty-five healthy controls of the same ethnicity served as a control group. Clinical disease activity was scored according to SLEDAI score. Accordingly, 110 patients had active disease and 35 patients had inactive disease. Mean levels of IL-6, TNF-α, and IL-1β were found to be significantly higher in SLE patients than healthy controls (P<0.001). Mean level of IL-6 for patients with active disease (70.45±68.32 pg/mL) was significantly higher (P=0.0430) than those of inactive disease patients (43.85±63.36 pg/mL). Mean level of TNF-α was 44.76±68.32 pg/mL for patients with active disease while it was 25.97±22.03 pg/mL for those with inactive disease and this difference was statistically significant (P=0.0161). Similar results were obtained for IL-1β (P=0.0002). Correlation between IL-6, TNF-α, and IL-1β serum levels and SLEDAI score was observed (r=0.20, r=0.27, and r=0.38, resp.). This study supports the role of these proinflammatory cytokines as inflammatory mediators in active stage of disease.http://dx.doi.org/10.1155/2014/385297 |
| spellingShingle | Vinod Umare Vandana Pradhan Milind Nadkar Anjali Rajadhyaksha Manisha Patwardhan Kanjaksha K. Ghosh Anita H. Nadkarni Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients Mediators of Inflammation |
| title | Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients |
| title_full | Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients |
| title_fullStr | Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients |
| title_full_unstemmed | Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients |
| title_short | Effect of Proinflammatory Cytokines (IL-6, TNF-α, and IL-1β) on Clinical Manifestations in Indian SLE Patients |
| title_sort | effect of proinflammatory cytokines il 6 tnf α and il 1β on clinical manifestations in indian sle patients |
| url | http://dx.doi.org/10.1155/2014/385297 |
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