The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters
A novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, whi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/3050486 |
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| _version_ | 1832562236935110656 |
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| author | Bing Ren Tian Jia Yue Liu Hu Rong Ge Zhi Zhong Wang Shao Yun Huang Yu Ying Wang Qing Huang Rui Xia Zhang |
| author_facet | Bing Ren Tian Jia Yue Liu Hu Rong Ge Zhi Zhong Wang Shao Yun Huang Yu Ying Wang Qing Huang Rui Xia Zhang |
| author_sort | Bing Ren Tian |
| collection | DOAJ |
| description | A novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, which correlated well with molecular transport through membranes and, therefore, enabled prediction of transport properties of drugs. |
| format | Article |
| id | doaj-art-09d68ea21efb4b0da5fbb2b016e762f7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-09d68ea21efb4b0da5fbb2b016e762f72025-02-03T01:23:05ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/30504863050486The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid EstersBing Ren Tian0Jia Yue Liu1Hu Rong Ge2Zhi Zhong Wang3Shao Yun Huang4Yu Ying Wang5Qing Huang6Rui Xia Zhang7School of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Physical Education, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Physical Education, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaSchool of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Pharmacy, The Third People’s Hospital of Yinchuan, Yinchuan 750004, ChinaA novel series of resveratrol modified by γ-aminobutyric acid esters were designed and synthesized. Then, the products were characterized by 1H-NMR, 13C-NMR, and MS, and the melting point was determined. Molecular water solubility, polar surface area, and octanol-water partition were calculated, which correlated well with molecular transport through membranes and, therefore, enabled prediction of transport properties of drugs.http://dx.doi.org/10.1155/2019/3050486 |
| spellingShingle | Bing Ren Tian Jia Yue Liu Hu Rong Ge Zhi Zhong Wang Shao Yun Huang Yu Ying Wang Qing Huang Rui Xia Zhang The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters Journal of Chemistry |
| title | The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters |
| title_full | The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters |
| title_fullStr | The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters |
| title_full_unstemmed | The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters |
| title_short | The Design, Synthesis, and Characterization of Resveratrol Derivatives Modified by Different γ-Aminobutyric Acid Esters |
| title_sort | design synthesis and characterization of resveratrol derivatives modified by different γ aminobutyric acid esters |
| url | http://dx.doi.org/10.1155/2019/3050486 |
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