Chimeric RNA in Cancer and Stem Cell Differentiation
Gene fusions are considered hallmarks of cancer which can be produced by chromosomal rearrangements. These DNA-level fusion events may result in the expression of chimeric RNAs; however, chimeric RNAs can be also produced by intergenic splicing events. Chimeric transcripts created by the latter mech...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/3178789 |
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| _version_ | 1832548932708728832 |
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| author | Justin Elfman Hui Li |
| author_facet | Justin Elfman Hui Li |
| author_sort | Justin Elfman |
| collection | DOAJ |
| description | Gene fusions are considered hallmarks of cancer which can be produced by chromosomal rearrangements. These DNA-level fusion events may result in the expression of chimeric RNAs; however, chimeric RNAs can be also produced by intergenic splicing events. Chimeric transcripts created by the latter mechanism are regulated at the transcriptional level and thus present additional modes of action and regulation. They have demonstrated importance in normal cell physiology, and their dysregulation can induce oncogenesis and impact cell differentiation. In this review, we outline proven mechanisms through which intergenically spliced chimeric RNAs are involved in carcinogenesis. We highlight their similarity to canonical chimeric RNAs resulting from gene fusions as well as their unique qualities. Additionally, we review known roles of chimeric RNA in cell differentiation and propose means through which chimeric RNAs may be valuable as stage-specific markers or as targets for expression profiling. |
| format | Article |
| id | doaj-art-09d40bb7dad443eba324217203824722 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-09d40bb7dad443eba3242172038247222025-02-03T06:12:37ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/31787893178789Chimeric RNA in Cancer and Stem Cell DifferentiationJustin Elfman0Hui Li1Department of Biochemistry and Molecular Genetics, University of Virginia, 22903, USADepartment of Biochemistry and Molecular Genetics, University of Virginia, 22903, USAGene fusions are considered hallmarks of cancer which can be produced by chromosomal rearrangements. These DNA-level fusion events may result in the expression of chimeric RNAs; however, chimeric RNAs can be also produced by intergenic splicing events. Chimeric transcripts created by the latter mechanism are regulated at the transcriptional level and thus present additional modes of action and regulation. They have demonstrated importance in normal cell physiology, and their dysregulation can induce oncogenesis and impact cell differentiation. In this review, we outline proven mechanisms through which intergenically spliced chimeric RNAs are involved in carcinogenesis. We highlight their similarity to canonical chimeric RNAs resulting from gene fusions as well as their unique qualities. Additionally, we review known roles of chimeric RNA in cell differentiation and propose means through which chimeric RNAs may be valuable as stage-specific markers or as targets for expression profiling.http://dx.doi.org/10.1155/2018/3178789 |
| spellingShingle | Justin Elfman Hui Li Chimeric RNA in Cancer and Stem Cell Differentiation Stem Cells International |
| title | Chimeric RNA in Cancer and Stem Cell Differentiation |
| title_full | Chimeric RNA in Cancer and Stem Cell Differentiation |
| title_fullStr | Chimeric RNA in Cancer and Stem Cell Differentiation |
| title_full_unstemmed | Chimeric RNA in Cancer and Stem Cell Differentiation |
| title_short | Chimeric RNA in Cancer and Stem Cell Differentiation |
| title_sort | chimeric rna in cancer and stem cell differentiation |
| url | http://dx.doi.org/10.1155/2018/3178789 |
| work_keys_str_mv | AT justinelfman chimericrnaincancerandstemcelldifferentiation AT huili chimericrnaincancerandstemcelldifferentiation |