Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is a major health threat around the world and is characterized by dysbiosis. Primary bile acids are synthesized in the liver and converted into secondary bile acids by gut microbiota. Recent studies support the role of bile acids in modulating dysbiosis and N...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/7659509 |
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| author | Caihua Wang Chunpeng Zhu Liming Shao Jun Ye Yimin Shen Yuezhong Ren |
| author_facet | Caihua Wang Chunpeng Zhu Liming Shao Jun Ye Yimin Shen Yuezhong Ren |
| author_sort | Caihua Wang |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is a major health threat around the world and is characterized by dysbiosis. Primary bile acids are synthesized in the liver and converted into secondary bile acids by gut microbiota. Recent studies support the role of bile acids in modulating dysbiosis and NAFLD, while the mechanisms are not well elucidated. Dysbiosis may alter the size and the composition of the bile acid pool, resulting in reduced signaling of bile acid receptors such as farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). These receptors are essential in lipid and glucose metabolism, and impaired bile acid signaling may cause NAFLD. Bile acids also reciprocally regulate the gut microbiota directly via antibacterial activity and indirectly via FXR. Therefore, bile acid signaling is closely linked to dysbiosis and NAFLD. During the past decade, stimulation of bile acid receptors with their agonists has been extensively explored for the treatment of NAFLD in both animal models and clinical trials. Early evidence has suggested the potential of bile acid receptor agonists in NAFLD management, but their long-term safety and effectiveness need further clarification. |
| format | Article |
| id | doaj-art-09cd77a275204c4d9b41e14133934339 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-09cd77a275204c4d9b41e141339343392025-02-03T01:27:50ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/76595097659509Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver DiseaseCaihua Wang0Chunpeng Zhu1Liming Shao2Jun Ye3Yimin Shen4Yuezhong Ren5Department of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, ChinaNonalcoholic fatty liver disease (NAFLD) is a major health threat around the world and is characterized by dysbiosis. Primary bile acids are synthesized in the liver and converted into secondary bile acids by gut microbiota. Recent studies support the role of bile acids in modulating dysbiosis and NAFLD, while the mechanisms are not well elucidated. Dysbiosis may alter the size and the composition of the bile acid pool, resulting in reduced signaling of bile acid receptors such as farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5). These receptors are essential in lipid and glucose metabolism, and impaired bile acid signaling may cause NAFLD. Bile acids also reciprocally regulate the gut microbiota directly via antibacterial activity and indirectly via FXR. Therefore, bile acid signaling is closely linked to dysbiosis and NAFLD. During the past decade, stimulation of bile acid receptors with their agonists has been extensively explored for the treatment of NAFLD in both animal models and clinical trials. Early evidence has suggested the potential of bile acid receptor agonists in NAFLD management, but their long-term safety and effectiveness need further clarification.http://dx.doi.org/10.1155/2019/7659509 |
| spellingShingle | Caihua Wang Chunpeng Zhu Liming Shao Jun Ye Yimin Shen Yuezhong Ren Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease Mediators of Inflammation |
| title | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease |
| title_full | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease |
| title_fullStr | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease |
| title_short | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease |
| title_sort | role of bile acids in dysbiosis and treatment of nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2019/7659509 |
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