The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden
Introduction. Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF i...
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2020-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/3981684 |
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| author | Szilvia Herczeg Joseph Galvin John J. Keaney Edward Keelan Roger Byrne Claire Howard Laszlo Geller Gabor Szeplaki |
| author_facet | Szilvia Herczeg Joseph Galvin John J. Keaney Edward Keelan Roger Byrne Claire Howard Laszlo Geller Gabor Szeplaki |
| author_sort | Szilvia Herczeg |
| collection | DOAJ |
| description | Introduction. Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF is focused on the left atrium (LA), the role of the right atrium (RA) is less well understood. We aimed to characterize the clinical determinates of the RA low-voltage burden and its relation to the LA scaring. Methods. We have included 36 patients who underwent catheter ablation for AF in a prospective observational study. In addition to LA mapping and ablation, high-density RA bipolar voltage maps (HD-EAM) were also reconstructed. The extent of the diseased RA tissue (≤0.5 mV) was quantified using the voltage histogram analysis tool (CARTO®3, Biosense Webster). Results. The percentage of RA diseased tissue burden was significantly higher in patients with a CHA2DS2-VASc score ≥ 2 p=0.0305, higher indexed LA volume on the CTA scan and on the HD‐EAM (p=0.0223 and p=0.0064, respectively), or higher indexed RA volume on the HD‐EAM p=0.0026. High RA diseased tissue burden predicted the presence of high LA diseased tissue burden (OR = 7.1, CI (95%): 1.3–38.9, p=0.0145), and there was a significant correlation of the same (r = 0.6461, p<0.0001). Conclusions. Determining the extent of the right atrial low-voltage burden might give useful clinical information. According to our results, the diseased tissue burden correlates well between the two atria: the right atrium mirrors the left atrium. |
| format | Article |
| id | doaj-art-09c2fe8b42cc45dca398d5689423eeb7 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-09c2fe8b42cc45dca398d5689423eeb72025-02-03T01:04:47ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/39816843981684The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar BurdenSzilvia Herczeg0Joseph Galvin1John J. Keaney2Edward Keelan3Roger Byrne4Claire Howard5Laszlo Geller6Gabor Szeplaki7Heart and Vascular Centre of Semmelweis University, 68 Varosmajor Street, 1122 Budapest, HungaryAtrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, IrelandAtrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, IrelandAtrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, IrelandHeart and Vascular Centre, Mater Private Hospital, Eccles Street, Dublin 7, IrelandAtrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, IrelandHeart and Vascular Centre of Semmelweis University, 68 Varosmajor Street, 1122 Budapest, HungaryAtrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, IrelandIntroduction. Growing evidence suggests that fibrotic changes can be observed in atrial fibrillation (AF) in both atria. Quantification of the scar burden during electroanatomical mapping might have important therapeutic and prognostic consequences. However, as the current invasive treatment of AF is focused on the left atrium (LA), the role of the right atrium (RA) is less well understood. We aimed to characterize the clinical determinates of the RA low-voltage burden and its relation to the LA scaring. Methods. We have included 36 patients who underwent catheter ablation for AF in a prospective observational study. In addition to LA mapping and ablation, high-density RA bipolar voltage maps (HD-EAM) were also reconstructed. The extent of the diseased RA tissue (≤0.5 mV) was quantified using the voltage histogram analysis tool (CARTO®3, Biosense Webster). Results. The percentage of RA diseased tissue burden was significantly higher in patients with a CHA2DS2-VASc score ≥ 2 p=0.0305, higher indexed LA volume on the CTA scan and on the HD‐EAM (p=0.0223 and p=0.0064, respectively), or higher indexed RA volume on the HD‐EAM p=0.0026. High RA diseased tissue burden predicted the presence of high LA diseased tissue burden (OR = 7.1, CI (95%): 1.3–38.9, p=0.0145), and there was a significant correlation of the same (r = 0.6461, p<0.0001). Conclusions. Determining the extent of the right atrial low-voltage burden might give useful clinical information. According to our results, the diseased tissue burden correlates well between the two atria: the right atrium mirrors the left atrium.http://dx.doi.org/10.1155/2020/3981684 |
| spellingShingle | Szilvia Herczeg Joseph Galvin John J. Keaney Edward Keelan Roger Byrne Claire Howard Laszlo Geller Gabor Szeplaki The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden Cardiology Research and Practice |
| title | The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden |
| title_full | The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden |
| title_fullStr | The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden |
| title_full_unstemmed | The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden |
| title_short | The Value of Voltage Histogram Analysis Derived Right Atrial Scar Burden in the Prediction of Left Atrial Scar Burden |
| title_sort | value of voltage histogram analysis derived right atrial scar burden in the prediction of left atrial scar burden |
| url | http://dx.doi.org/10.1155/2020/3981684 |
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