Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review
Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2023/1512974 |
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| author | Leonardo da Rocha Sousa Nildomar Ribeiro Viana Angélica Gomes Coêlho Celma de Oliveira Barbosa Débora Santos Lula Barros Maria do Carmo de Carvalho e Martins Ricardo Martins Ramos Daniel Dias Rufino Arcanjo |
| author_facet | Leonardo da Rocha Sousa Nildomar Ribeiro Viana Angélica Gomes Coêlho Celma de Oliveira Barbosa Débora Santos Lula Barros Maria do Carmo de Carvalho e Martins Ricardo Martins Ramos Daniel Dias Rufino Arcanjo |
| author_sort | Leonardo da Rocha Sousa |
| collection | DOAJ |
| description | Monoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent years. Due to nature’s complex biosynthetic machinery, they also exhibit a reasonable degree of structural complexity/diversity for further analysis in structure-activity studies. Therefore, monoterpenes as antidiabetic agents have been investigated by recent in vitro and in vivo studies extensively reported in the scientific literature and claimed by patent documents. The purpose of this survey is to provide a comprehensive and prospective review concerning the potential applications of monoterpenes in the treatment of diabetes. The data for this research were collected through the specialized databases PubMed, Scopus, Web of Science, and ScienceDirect between the years 2014 and 2022, as well as the patent databases EPO, WIPO, and USPTO. The research used 76 articles published in the leading journals in the field. The main effect observed was the antidiabetic activity of monoterpenes. This review showed that monoterpenes can be considered promising agents for prevention and/or treatment of diabetes as well as have a marked pharmaceutical potential for the development of bioproducts for therapeutics applications. |
| format | Article |
| id | doaj-art-09c2e7114a224937a5e5c25ada6f953b |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-09c2e7114a224937a5e5c25ada6f953b2025-02-03T05:57:02ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902023-01-01202310.1155/2023/1512974Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective ReviewLeonardo da Rocha Sousa0Nildomar Ribeiro Viana1Angélica Gomes Coêlho2Celma de Oliveira Barbosa3Débora Santos Lula Barros4Maria do Carmo de Carvalho e Martins5Ricardo Martins Ramos6Daniel Dias Rufino Arcanjo7LAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyLAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyLAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyLAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyDepartment of PharmacyLAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyLaBME–Laboratory of Molecular Biology and EpidemiologyLAFMOL–Laboratory of Functional and Molecular Studies in PhysiopharmacologyMonoterpenes are secondary metabolites of plants belonging to the terpenoid class of natural products. They are the most abundant components of essential oils that are generally considered to have various pharmacological properties. These compounds are reported to have antidiabetic effects in recent years. Due to nature’s complex biosynthetic machinery, they also exhibit a reasonable degree of structural complexity/diversity for further analysis in structure-activity studies. Therefore, monoterpenes as antidiabetic agents have been investigated by recent in vitro and in vivo studies extensively reported in the scientific literature and claimed by patent documents. The purpose of this survey is to provide a comprehensive and prospective review concerning the potential applications of monoterpenes in the treatment of diabetes. The data for this research were collected through the specialized databases PubMed, Scopus, Web of Science, and ScienceDirect between the years 2014 and 2022, as well as the patent databases EPO, WIPO, and USPTO. The research used 76 articles published in the leading journals in the field. The main effect observed was the antidiabetic activity of monoterpenes. This review showed that monoterpenes can be considered promising agents for prevention and/or treatment of diabetes as well as have a marked pharmaceutical potential for the development of bioproducts for therapeutics applications.http://dx.doi.org/10.1155/2023/1512974 |
| spellingShingle | Leonardo da Rocha Sousa Nildomar Ribeiro Viana Angélica Gomes Coêlho Celma de Oliveira Barbosa Débora Santos Lula Barros Maria do Carmo de Carvalho e Martins Ricardo Martins Ramos Daniel Dias Rufino Arcanjo Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review Advances in Pharmacological and Pharmaceutical Sciences |
| title | Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review |
| title_full | Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review |
| title_fullStr | Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review |
| title_full_unstemmed | Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review |
| title_short | Use of Monoterpenes as Potential Therapeutics in Diabetes Mellitus: A Prospective Review |
| title_sort | use of monoterpenes as potential therapeutics in diabetes mellitus a prospective review |
| url | http://dx.doi.org/10.1155/2023/1512974 |
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