Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study
BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1502139/full |
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| author | Suming Dai Ping Wang Sijia Wang Sijia Wang Hong Chen Zhixin Cui Wenhai Lu Wenhai Lu Ziyi Zhou Ziyi Zhou Nan Zhang Zhuo Wang Tengfei Lin Tengfei Lin Yun Song Yun Song Lishun Liu Lishun Liu Xiao Huang Ping Chen Genfu Tang Yong Duan Yong Duan Hao Zhang Binyan Wang Binyan Wang Binyan Wang Yan Yang Yan Yang Yan Yang Zezhong Tian |
| author_facet | Suming Dai Ping Wang Sijia Wang Sijia Wang Hong Chen Zhixin Cui Wenhai Lu Wenhai Lu Ziyi Zhou Ziyi Zhou Nan Zhang Zhuo Wang Tengfei Lin Tengfei Lin Yun Song Yun Song Lishun Liu Lishun Liu Xiao Huang Ping Chen Genfu Tang Yong Duan Yong Duan Hao Zhang Binyan Wang Binyan Wang Binyan Wang Yan Yang Yan Yang Yan Yang Zezhong Tian |
| author_sort | Suming Dai |
| collection | DOAJ |
| description | BackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants were categorized into different co-exposure patterns using the unsupervised K-means clustering method. The multiple linear regression model was used for subsequent analyses.ResultsParticipants were classified into two co-exposure patterns of fat-soluble vitamins. The levels of vitamins were relatively low in pattern 1, compared to pattern 2. Participants in pattern 2 had no significantly different blood pressure levels compared to pattern 1. However, the plasma 25-hydroxyvitamin D3 (VD3) levels were negatively associated with SBP (logarithmic 10 transformed) (β = −0.002, 95% CI: −0.004, 0); participants in the fourth α-tocopherol quartile had mean SBP levels that were 1.02% (95% CI: 0.43, 1.61%) greater than those in the lowest quartile (p for trend <0.01). In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.DiscussionAlthough no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma α-tocopherol levels may offset the potential protective effect of plasma VD3 on blood pressure among hypertensive adults. This provided a novel perspective for exploring the joint effects of fat-soluble vitamins on blood pressure. Further studies are warranted to better understand the implications. |
| format | Article |
| id | doaj-art-09c2399f3fbf49a4aa5e0e055428f711 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-09c2399f3fbf49a4aa5e0e055428f7112025-01-23T16:53:05ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15021391502139Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional studySuming Dai0Ping Wang1Sijia Wang2Sijia Wang3Hong Chen4Zhixin Cui5Wenhai Lu6Wenhai Lu7Ziyi Zhou8Ziyi Zhou9Nan Zhang10Zhuo Wang11Tengfei Lin12Tengfei Lin13Yun Song14Yun Song15Lishun Liu16Lishun Liu17Xiao Huang18Ping Chen19Genfu Tang20Yong Duan21Yong Duan22Hao Zhang23Binyan Wang24Binyan Wang25Binyan Wang26Yan Yang27Yan Yang28Yan Yang29Zezhong Tian30School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaShenzhen Luohu District Chronic Disease Prevention and Treatment Hospital, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaPingdi Public Health Service Center, Shenzhen, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaShenzhen Evergreen Medical Institute, Shenzhen, ChinaDepartment of Cardiology, Peking University First Hospital, Beijing, ChinaKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, ChinaKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, ChinaCollege of Pharmacy, Jinan University, Guangzhou, ChinaKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, ChinaInstitute of Biomedicine, Anhui Medical University, Hefei, ChinaGraduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaShenzhen Evergreen Medical Institute, Shenzhen, China0Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, ChinaCollege of Pharmacy, Jinan University, Guangzhou, China1School of Heath Administration, Anhui Medical University, Hefei, China2Yunnan Key Laboratory of Laboratory Medicine, Kunming, China3Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, ChinaShenzhen Evergreen Medical Institute, Shenzhen, ChinaInstitute of Biomedicine, Anhui Medical University, Hefei, China4National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China5Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China6Guangdong Provincial Engineering Laboratory for Nutrition Translation, Guangzhou, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, ChinaBackgroundExisting epidemiological studies investigated the association between a single vitamin and hypertension. However, the potential relationship between the level of circulating multivitamins and blood pressure has not been explored. We aimed to investigate the association between multiple fat-soluble vitamin levels and blood pressure.MethodsA total of 2052 participants with essential hypertension were sampled nationwide. The plasma concentrations of fat-soluble vitamins (A, E, D, and K) were assessed using liquid chromatography coupled with the mass spectrometry method. Participants were categorized into different co-exposure patterns using the unsupervised K-means clustering method. The multiple linear regression model was used for subsequent analyses.ResultsParticipants were classified into two co-exposure patterns of fat-soluble vitamins. The levels of vitamins were relatively low in pattern 1, compared to pattern 2. Participants in pattern 2 had no significantly different blood pressure levels compared to pattern 1. However, the plasma 25-hydroxyvitamin D3 (VD3) levels were negatively associated with SBP (logarithmic 10 transformed) (β = −0.002, 95% CI: −0.004, 0); participants in the fourth α-tocopherol quartile had mean SBP levels that were 1.02% (95% CI: 0.43, 1.61%) greater than those in the lowest quartile (p for trend <0.01). In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.DiscussionAlthough no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma α-tocopherol levels may offset the potential protective effect of plasma VD3 on blood pressure among hypertensive adults. This provided a novel perspective for exploring the joint effects of fat-soluble vitamins on blood pressure. Further studies are warranted to better understand the implications.https://www.frontiersin.org/articles/10.3389/fnut.2024.1502139/fullfat-soluble vitaminsco-exposure patternsblood pressureessential hypertensioncross-sectional study |
| spellingShingle | Suming Dai Ping Wang Sijia Wang Sijia Wang Hong Chen Zhixin Cui Wenhai Lu Wenhai Lu Ziyi Zhou Ziyi Zhou Nan Zhang Zhuo Wang Tengfei Lin Tengfei Lin Yun Song Yun Song Lishun Liu Lishun Liu Xiao Huang Ping Chen Genfu Tang Yong Duan Yong Duan Hao Zhang Binyan Wang Binyan Wang Binyan Wang Yan Yang Yan Yang Yan Yang Zezhong Tian Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study Frontiers in Nutrition fat-soluble vitamins co-exposure patterns blood pressure essential hypertension cross-sectional study |
| title | Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study |
| title_full | Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study |
| title_fullStr | Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study |
| title_full_unstemmed | Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study |
| title_short | Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study |
| title_sort | association between fat soluble vitamin co exposure patterns and blood pressure in people with hypertension a cross sectional study |
| topic | fat-soluble vitamins co-exposure patterns blood pressure essential hypertension cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1502139/full |
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