Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps
Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disease with a high postoperative recurrence rate. This study is aimed at exploring the expression of B cell-activating factor (BAFF) in CRSwNP and its association with postoperative recurrence. Metho...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/7338692 |
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| author | Fang Zhang Zhenhang Xu Xi He Yi Sun Chong Zhao Jianhui Zhang |
| author_facet | Fang Zhang Zhenhang Xu Xi He Yi Sun Chong Zhao Jianhui Zhang |
| author_sort | Fang Zhang |
| collection | DOAJ |
| description | Background. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disease with a high postoperative recurrence rate. This study is aimed at exploring the expression of B cell-activating factor (BAFF) in CRSwNP and its association with postoperative recurrence. Methods. A total of 80 CRSwNP patients, including 40 primary CRSwNP patients and 40 recurrent CRSwNP patients, 40 chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and 40 healthy controls (HC) were enrolled in this study, and the serum and tissue samples were collected. The circulating and tissue BAFF expressions were detected by enzyme-linked immunosorbent assay reverse transcription-polymerase chain reaction and immunohistochemistry. Their clinical values for predicting postoperative recurrence of CRSwNP were evaluated. Results. We determined serum levels of BAFF were remarkably increased in the CRSwNP group than the CRSsNP and HC groups (P<0.05), and higher concentrations of BAFF were associated with peripheral eosinophil percentage (r=0.614, P<0.001). The serum BAFF concentrations were significantly higher in the recurrent CRSwNP group in comparison with the primary group (P<0.05). Multivariate analysis and receiver operating characteristic (ROC) curve presented that serum BAFF levels were associated with the postoperative recurrence in CRSwNP patients (P<0.05). Moreover, tissue BAFF levels were significantly increased in the CRSwNP group than the HC group, especially in the recurrent CRSwNP group (P<0.05), and enhanced BAFF RNA expressions were correlated with serum BAFF levels (r=0.703, P<0.001). Conclusion. Our results elucidated that the BAFF expression was enhanced in CRSwNP patients and associated with postoperative recurrence. BAFF could be a serologic biomarker for predicting postoperative recurrence in CRSwNP patients. |
| format | Article |
| id | doaj-art-09b092d36263456fac39cc80ee39d4ea |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-09b092d36263456fac39cc80ee39d4ea2025-02-03T07:26:19ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/7338692Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal PolypsFang Zhang0Zhenhang Xu1Xi He2Yi Sun3Chong Zhao4Jianhui Zhang5Department of OtolaryngologyDepartment of Biomedical SciencesDepartment of OtolaryngologyDepartment of OtolaryngologyDepartment of OtolaryngologyDepartment of OtolaryngologyBackground. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper airway inflammatory disease with a high postoperative recurrence rate. This study is aimed at exploring the expression of B cell-activating factor (BAFF) in CRSwNP and its association with postoperative recurrence. Methods. A total of 80 CRSwNP patients, including 40 primary CRSwNP patients and 40 recurrent CRSwNP patients, 40 chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and 40 healthy controls (HC) were enrolled in this study, and the serum and tissue samples were collected. The circulating and tissue BAFF expressions were detected by enzyme-linked immunosorbent assay reverse transcription-polymerase chain reaction and immunohistochemistry. Their clinical values for predicting postoperative recurrence of CRSwNP were evaluated. Results. We determined serum levels of BAFF were remarkably increased in the CRSwNP group than the CRSsNP and HC groups (P<0.05), and higher concentrations of BAFF were associated with peripheral eosinophil percentage (r=0.614, P<0.001). The serum BAFF concentrations were significantly higher in the recurrent CRSwNP group in comparison with the primary group (P<0.05). Multivariate analysis and receiver operating characteristic (ROC) curve presented that serum BAFF levels were associated with the postoperative recurrence in CRSwNP patients (P<0.05). Moreover, tissue BAFF levels were significantly increased in the CRSwNP group than the HC group, especially in the recurrent CRSwNP group (P<0.05), and enhanced BAFF RNA expressions were correlated with serum BAFF levels (r=0.703, P<0.001). Conclusion. Our results elucidated that the BAFF expression was enhanced in CRSwNP patients and associated with postoperative recurrence. BAFF could be a serologic biomarker for predicting postoperative recurrence in CRSwNP patients.http://dx.doi.org/10.1155/2022/7338692 |
| spellingShingle | Fang Zhang Zhenhang Xu Xi He Yi Sun Chong Zhao Jianhui Zhang Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps Mediators of Inflammation |
| title | Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps |
| title_full | Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps |
| title_fullStr | Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps |
| title_full_unstemmed | Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps |
| title_short | Increased B Cell-Activating Factor Expression Is Associated with Postoperative Recurrence of Chronic Rhinosinusitis with Nasal Polyps |
| title_sort | increased b cell activating factor expression is associated with postoperative recurrence of chronic rhinosinusitis with nasal polyps |
| url | http://dx.doi.org/10.1155/2022/7338692 |
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