Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis
Gastrointestinal motility is impaired in a substantial proportion of patients with cirrhosis. Cirrhosis-related autonomic neuropathy, increased nitric oxide production, and gut hormonal changes have been implicated. Oesophageal dysmotility has been associated with increased frequency of abnormal gas...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/8270310 |
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| author | Eleni Theocharidou Ameet Dhar David Patch |
| author_facet | Eleni Theocharidou Ameet Dhar David Patch |
| author_sort | Eleni Theocharidou |
| collection | DOAJ |
| description | Gastrointestinal motility is impaired in a substantial proportion of patients with cirrhosis. Cirrhosis-related autonomic neuropathy, increased nitric oxide production, and gut hormonal changes have been implicated. Oesophageal dysmotility has been associated with increased frequency of abnormal gastro-oesophageal reflux. Impaired gastric emptying and accommodation may result in early satiety and may have an impact on the nutritional status of these patients. Small intestinal dysmotility might be implicated in small intestinal bacterial overgrowth and increased bacterial translocation. The latter has been implicated in the pathophysiology of hepatic encephalopathy and spontaneous bacterial peritonitis. Enhanced colonic motility is usually associated with the use of lactulose. Pharmacological interventions aiming to alter gastrointestinal motility in cirrhosis could potentially have a beneficial effect reducing the risk of hepatic decompensation and improving prognosis. |
| format | Article |
| id | doaj-art-099ed3626a1e44e3888af1555c7d2a63 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-099ed3626a1e44e3888af1555c7d2a632025-02-03T05:45:56ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/82703108270310Gastrointestinal Motility Disorders and Their Clinical Implications in CirrhosisEleni Theocharidou0Ameet Dhar1David Patch2The Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hampstead NHS Trust, University College London, London, UKSection of Hepatology, Department of Medicine, St Mary’s Hospital, Imperial College London, London, UKThe Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital, Royal Free Hampstead NHS Trust, University College London, London, UKGastrointestinal motility is impaired in a substantial proportion of patients with cirrhosis. Cirrhosis-related autonomic neuropathy, increased nitric oxide production, and gut hormonal changes have been implicated. Oesophageal dysmotility has been associated with increased frequency of abnormal gastro-oesophageal reflux. Impaired gastric emptying and accommodation may result in early satiety and may have an impact on the nutritional status of these patients. Small intestinal dysmotility might be implicated in small intestinal bacterial overgrowth and increased bacterial translocation. The latter has been implicated in the pathophysiology of hepatic encephalopathy and spontaneous bacterial peritonitis. Enhanced colonic motility is usually associated with the use of lactulose. Pharmacological interventions aiming to alter gastrointestinal motility in cirrhosis could potentially have a beneficial effect reducing the risk of hepatic decompensation and improving prognosis.http://dx.doi.org/10.1155/2017/8270310 |
| spellingShingle | Eleni Theocharidou Ameet Dhar David Patch Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis Gastroenterology Research and Practice |
| title | Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis |
| title_full | Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis |
| title_fullStr | Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis |
| title_full_unstemmed | Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis |
| title_short | Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis |
| title_sort | gastrointestinal motility disorders and their clinical implications in cirrhosis |
| url | http://dx.doi.org/10.1155/2017/8270310 |
| work_keys_str_mv | AT elenitheocharidou gastrointestinalmotilitydisordersandtheirclinicalimplicationsincirrhosis AT ameetdhar gastrointestinalmotilitydisordersandtheirclinicalimplicationsincirrhosis AT davidpatch gastrointestinalmotilitydisordersandtheirclinicalimplicationsincirrhosis |