Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage

Eomesodermin in conjunction with the BAF complex promotes expansion and invasion of the trophectoderm lineage

Abstract The T-box transcription factor (TF) Eomesodermin/Tbr2 (Eomes) is essential for maintenance of the trophectoderm (TE) lineage, but the molecular mechanisms underlying this critical role remain obscure. Here, we show in trophoblast stem cells (TSCs) that Eomes partners with several TE-specifi...

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Bibliographic Details
Main Authors: Alexandra Maria Bisia, Maria-Eleni Xypolita, Elizabeth K. Bikoff, Elizabeth J. Robertson, Ita Costello
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60417-w
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