Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases
Objective. Periodontitis is a common disorder that leads to the loss of both tooth and personal well-being, contributing to worsen the risk for metabolic and cardiovascular diseases. Recently, probiotics, characterized by rapid oral dispersion, have been topically used. Here, we present data of a mu...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2022/5007930 |
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| _version_ | 1832550395837153280 |
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| author | Giuseppe Giannini Irene Ragusa Giulia Nerina Nardone Sara Soldi Marina Elli Piera Valenti Luigi Rosa Emanuele Marra Daniela Stoppoloni Emilio Merlo Pich |
| author_facet | Giuseppe Giannini Irene Ragusa Giulia Nerina Nardone Sara Soldi Marina Elli Piera Valenti Luigi Rosa Emanuele Marra Daniela Stoppoloni Emilio Merlo Pich |
| author_sort | Giuseppe Giannini |
| collection | DOAJ |
| description | Objective. Periodontitis is a common disorder that leads to the loss of both tooth and personal well-being, contributing to worsen the risk for metabolic and cardiovascular diseases. Recently, probiotics, characterized by rapid oral dispersion, have been topically used. Here, we present data of a mucoadhesive gel containing probiotics, capable of ensuring a slow release of bacteria to prevent and treat periodontitis. Methods. An original mucoadhesive gel (AL0005) that is anhydrous and of food grade, loaded with the blend of lactobacilli and plants’ dry extracts, has been assayed. Results. The release kinetics of the bacterial mixture in different experimental models in vitro, including simulated saliva or physiological solutions, showed a significant and stable release for 5–8 hours. In one in vivo study of a mouse model of periodontitis, a locally applied mucoadhesive gel enriched with probiotic strains improved significantly the tissue pathology when compared with vehicle-exposed mice. Conclusions. Together, the results suggest that this mucoadhesive gel can be useful in the normalization of the gum bacterial flora and improvement of the tissue pathology of gum disorders. |
| format | Article |
| id | doaj-art-0987a513a57f47c2acc0abf399e285a9 |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-0987a513a57f47c2acc0abf399e285a92025-02-03T06:06:48ZengWileyInternational Journal of Dentistry1687-87362022-01-01202210.1155/2022/5007930Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal DiseasesGiuseppe Giannini0Irene Ragusa1Giulia Nerina Nardone2Sara Soldi3Marina Elli4Piera Valenti5Luigi Rosa6Emanuele Marra7Daniela Stoppoloni8Emilio Merlo Pich9R&D Alfasigma S.p.A.Labomar S.p.A.Labomar S.p.A.AAT–Advanced Analytical Technologies SrlAAT–Advanced Analytical Technologies SrlDepartment of Public Health and Infectious DiseasesDepartment of Public Health and Infectious DiseasesTakis s.r.lTakis s.r.lR&D Alfasigma S.p.A.Objective. Periodontitis is a common disorder that leads to the loss of both tooth and personal well-being, contributing to worsen the risk for metabolic and cardiovascular diseases. Recently, probiotics, characterized by rapid oral dispersion, have been topically used. Here, we present data of a mucoadhesive gel containing probiotics, capable of ensuring a slow release of bacteria to prevent and treat periodontitis. Methods. An original mucoadhesive gel (AL0005) that is anhydrous and of food grade, loaded with the blend of lactobacilli and plants’ dry extracts, has been assayed. Results. The release kinetics of the bacterial mixture in different experimental models in vitro, including simulated saliva or physiological solutions, showed a significant and stable release for 5–8 hours. In one in vivo study of a mouse model of periodontitis, a locally applied mucoadhesive gel enriched with probiotic strains improved significantly the tissue pathology when compared with vehicle-exposed mice. Conclusions. Together, the results suggest that this mucoadhesive gel can be useful in the normalization of the gum bacterial flora and improvement of the tissue pathology of gum disorders.http://dx.doi.org/10.1155/2022/5007930 |
| spellingShingle | Giuseppe Giannini Irene Ragusa Giulia Nerina Nardone Sara Soldi Marina Elli Piera Valenti Luigi Rosa Emanuele Marra Daniela Stoppoloni Emilio Merlo Pich Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases International Journal of Dentistry |
| title | Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases |
| title_full | Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases |
| title_fullStr | Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases |
| title_full_unstemmed | Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases |
| title_short | Probiotics-Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases |
| title_sort | probiotics containing mucoadhesive gel for targeting the dysbiosis associated with periodontal diseases |
| url | http://dx.doi.org/10.1155/2022/5007930 |
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