Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits
Early weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/6430696 |
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| author | Dina Sibouakaz Khira Othmani-Mecif Amirouche Fernane Abdennour Taghlit Yasmina Benazzoug |
| author_facet | Dina Sibouakaz Khira Othmani-Mecif Amirouche Fernane Abdennour Taghlit Yasmina Benazzoug |
| author_sort | Dina Sibouakaz |
| collection | DOAJ |
| description | Early weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. Experiments were carried on 24 prepubertal New Zealand white rabbits, randomly assigned to male and female control (MC and FC, resp.) or HFD (MHFD and FHFD, resp.) groups (n=6) for 3 months. Body and heart weights and some biochemical and oxidative stress parameters such as lipids, calcium, CKMB, MDA, uric acid, ascorbic acid, and AOA are evaluated in plasma and the left ventricle. Under HFD effect, plasma parameters, such as lipids (TL, PL, and LDL-C), MDA, and CK-MB, increase more significantly in male than in female groups, when AA decreases. Some cardiac parameters such as TG and UA increase, when AA and AOA decrease; these variations are more significant in FHFD. In both male and female rabbits, HFD caused changes in heart ultrastructure, junctional complexes, mitochondria size and form, and so on. Early HFD feeding induced overweight, oxidative stress, and metabolic alterations in plasma and the heart of prepubertal rabbits, whereas lipotoxicity has especially a negative impact on male plasma but affects more the female heart ultrastructure. |
| format | Article |
| id | doaj-art-097d29fc871d4c89b9018bef57702e27 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-097d29fc871d4c89b9018bef57702e272025-02-03T06:00:23ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/64306966430696Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal RabbitsDina Sibouakaz0Khira Othmani-Mecif1Amirouche Fernane2Abdennour Taghlit3Yasmina Benazzoug4Laboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, AlgeriaLaboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, AlgeriaLaboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, AlgeriaLaboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, AlgeriaLaboratory of Cellular and Molecular Biology, Team of ECM Remodeling Biochemistry, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, BP 32, EL Alia, 16111 Algiers, AlgeriaEarly weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. Experiments were carried on 24 prepubertal New Zealand white rabbits, randomly assigned to male and female control (MC and FC, resp.) or HFD (MHFD and FHFD, resp.) groups (n=6) for 3 months. Body and heart weights and some biochemical and oxidative stress parameters such as lipids, calcium, CKMB, MDA, uric acid, ascorbic acid, and AOA are evaluated in plasma and the left ventricle. Under HFD effect, plasma parameters, such as lipids (TL, PL, and LDL-C), MDA, and CK-MB, increase more significantly in male than in female groups, when AA decreases. Some cardiac parameters such as TG and UA increase, when AA and AOA decrease; these variations are more significant in FHFD. In both male and female rabbits, HFD caused changes in heart ultrastructure, junctional complexes, mitochondria size and form, and so on. Early HFD feeding induced overweight, oxidative stress, and metabolic alterations in plasma and the heart of prepubertal rabbits, whereas lipotoxicity has especially a negative impact on male plasma but affects more the female heart ultrastructure.http://dx.doi.org/10.1155/2018/6430696 |
| spellingShingle | Dina Sibouakaz Khira Othmani-Mecif Amirouche Fernane Abdennour Taghlit Yasmina Benazzoug Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits Analytical Cellular Pathology |
| title | Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits |
| title_full | Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits |
| title_fullStr | Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits |
| title_full_unstemmed | Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits |
| title_short | Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet in Female and Male Prepubertal Rabbits |
| title_sort | biochemical and ultrastructural cardiac changes induced by high fat diet in female and male prepubertal rabbits |
| url | http://dx.doi.org/10.1155/2018/6430696 |
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