Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist
Lecanemab and donanemab have received full U.S. Food and Drug Administration (FDA) approval, and subsequently, lecanemab has been approved by the Korean FDA and it has recently entered commercial use in Korea. This has increased interest in anti-amyloid immunotherapy for Alzheimer’s disease. Anti...
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| Format: | Article |
| Language: | English |
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The Korean Society of Radiology
2025-01-01
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| Series: | Journal of the Korean Society of Radiology |
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| Online Access: | https://doi.org/10.3348/jksr.2024.0140 |
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| author | So Yeong Jeong Chong Hyun Suh Jae-Sung Lim Yangsean Choi Ho Sung Kim Sang Joon Kim Jae-Hong Lee |
| author_facet | So Yeong Jeong Chong Hyun Suh Jae-Sung Lim Yangsean Choi Ho Sung Kim Sang Joon Kim Jae-Hong Lee |
| author_sort | So Yeong Jeong |
| collection | DOAJ |
| description | Lecanemab and donanemab have received full U.S. Food and Drug Administration (FDA) approval,
and subsequently, lecanemab has been approved by the Korean FDA and it has recently
entered commercial use in Korea. This has increased interest in anti-amyloid immunotherapy
for Alzheimer’s disease. Anti-amyloid immunotherapy has shown potential to
modify the progression of the disease by specifically binding to amyloid β, a key pathological
product in Alzheimer’s disease, and eliminating accumulated amyloid plaques in the
brain. However, this treatment can be accompanied by a side-effect, amyloid-related imaging
abnormalities (ARIA), which requires periodic monitoring by MRI. It is crucial to detect
ARIA and accurately assess the severity by radiology. The role of the radiologist is important
in this context, requiring proficiency in basic knowledge of ARIA, and in diagnosing/evaluating
ARIA. This review aims to comprehensively cover aspects of ARIA, including its definition,
pathophysiology, incidence, risk factors, assessment of severity by radiology, differential diagnosis,
and management. |
| format | Article |
| id | doaj-art-0972e7b8e6e34053a457e4468a34c5a2 |
| institution | Kabale University |
| issn | 2951-0805 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | Journal of the Korean Society of Radiology |
| spelling | doaj-art-0972e7b8e6e34053a457e4468a34c5a22025-01-31T07:14:41ZengThe Korean Society of RadiologyJournal of the Korean Society of Radiology2951-08052025-01-018611733https://doi.org/10.3348/jksr.2024.0140Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the RadiologistSo Yeong JeongChong Hyun SuhJae-Sung LimYangsean ChoiHo Sung KimSang Joon KimJae-Hong LeeLecanemab and donanemab have received full U.S. Food and Drug Administration (FDA) approval, and subsequently, lecanemab has been approved by the Korean FDA and it has recently entered commercial use in Korea. This has increased interest in anti-amyloid immunotherapy for Alzheimer’s disease. Anti-amyloid immunotherapy has shown potential to modify the progression of the disease by specifically binding to amyloid β, a key pathological product in Alzheimer’s disease, and eliminating accumulated amyloid plaques in the brain. However, this treatment can be accompanied by a side-effect, amyloid-related imaging abnormalities (ARIA), which requires periodic monitoring by MRI. It is crucial to detect ARIA and accurately assess the severity by radiology. The role of the radiologist is important in this context, requiring proficiency in basic knowledge of ARIA, and in diagnosing/evaluating ARIA. This review aims to comprehensively cover aspects of ARIA, including its definition, pathophysiology, incidence, risk factors, assessment of severity by radiology, differential diagnosis, and management.https://doi.org/10.3348/jksr.2024.0140alzheimer diseasedementiaimmunotherapy |
| spellingShingle | So Yeong Jeong Chong Hyun Suh Jae-Sung Lim Yangsean Choi Ho Sung Kim Sang Joon Kim Jae-Hong Lee Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist Journal of the Korean Society of Radiology alzheimer disease dementia immunotherapy |
| title | Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist |
| title_full | Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist |
| title_fullStr | Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist |
| title_full_unstemmed | Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist |
| title_short | Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist |
| title_sort | anti amyloid imaging abnormality in the era of anti amyloid beta monoclonal antibodies recent updates for the radiologist |
| topic | alzheimer disease dementia immunotherapy |
| url | https://doi.org/10.3348/jksr.2024.0140 |
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