Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy
An analysis of causes leading to pain recurrence in patients with polymyalgia rheumatica (PR) after tapering down the dose of glucocorticosteroids (GCS) is presented. True exacerbations resulting from the main disease recurrence and pseudo-exacerbations when the resumption of pain syndrome is not du...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2023-02-01
|
| Series: | Klinicist |
| Subjects: | |
| Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/512 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467040245481472 |
|---|---|
| author | N. V. Bunchuk |
| author_facet | N. V. Bunchuk |
| author_sort | N. V. Bunchuk |
| collection | DOAJ |
| description | An analysis of causes leading to pain recurrence in patients with polymyalgia rheumatica (PR) after tapering down the dose of glucocorticosteroids (GCS) is presented. True exacerbations resulting from the main disease recurrence and pseudo-exacerbations when the resumption of pain syndrome is not due inflammation but because of other causes – steroid myopathy or chronic adrenal insufficiency (AI) are identified. The experience of using tocilizumab, an inhibitor of interleukin-6 receptors, as steroid-sparing agent in patients with PR is considered. The factors contributing to pain syndrome development, which can mimic exacerbations of PR (associated myofascial pain, vitamin D deficiency, etc.) are indicated. The methodology for AI diagnosis in patients receiving GCS therapy is discussed in detail. Recommendations for the rational AI therapy including acute cases are given. |
| format | Article |
| id | doaj-art-0971b9f651da405a8e7eb75ba8db1a62 |
| institution | Kabale University |
| issn | 1818-8338 |
| language | Russian |
| publishDate | 2023-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj-art-0971b9f651da405a8e7eb75ba8db1a622025-08-20T03:39:14ZrusABV-pressKlinicist1818-83382023-02-01164273210.17650/1818-8338-2022-16-4-K670391Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapyN. V. Bunchuk0The Cecil+ ClinicAn analysis of causes leading to pain recurrence in patients with polymyalgia rheumatica (PR) after tapering down the dose of glucocorticosteroids (GCS) is presented. True exacerbations resulting from the main disease recurrence and pseudo-exacerbations when the resumption of pain syndrome is not due inflammation but because of other causes – steroid myopathy or chronic adrenal insufficiency (AI) are identified. The experience of using tocilizumab, an inhibitor of interleukin-6 receptors, as steroid-sparing agent in patients with PR is considered. The factors contributing to pain syndrome development, which can mimic exacerbations of PR (associated myofascial pain, vitamin D deficiency, etc.) are indicated. The methodology for AI diagnosis in patients receiving GCS therapy is discussed in detail. Recommendations for the rational AI therapy including acute cases are given.https://klinitsist.abvpress.ru/Klin/article/view/512polymyalgia rheumaticaglucocorticoid treatmenttocilizumabchronic adrenal insufficiencysteroid myopathy |
| spellingShingle | N. V. Bunchuk Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy Klinicist polymyalgia rheumatica glucocorticoid treatment tocilizumab chronic adrenal insufficiency steroid myopathy |
| title | Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| title_full | Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| title_fullStr | Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| title_full_unstemmed | Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| title_short | Relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| title_sort | relapses of pain syndrome in patients with polymyalgia rheumatica during reduction of glucocorticoid therapy |
| topic | polymyalgia rheumatica glucocorticoid treatment tocilizumab chronic adrenal insufficiency steroid myopathy |
| url | https://klinitsist.abvpress.ru/Klin/article/view/512 |
| work_keys_str_mv | AT nvbunchuk relapsesofpainsyndromeinpatientswithpolymyalgiarheumaticaduringreductionofglucocorticoidtherapy |