Evaluation of the EndoPAT as a Tool to Assess Endothelial Function
Endothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions. We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive measurements and assessed its discriminating power i...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/904141 |
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| _version_ | 1832554335306776576 |
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| author | M. Moerland A. J. Kales L. Schrier M. G. J. van Dongen D. Bradnock J. Burggraaf |
| author_facet | M. Moerland A. J. Kales L. Schrier M. G. J. van Dongen D. Bradnock J. Burggraaf |
| author_sort | M. Moerland |
| collection | DOAJ |
| description | Endothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions. We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive measurements and assessed its discriminating power in different populations.
Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%). Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05). The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46). This suggests that at present the EndoPAT might not be suitable to assess (changes in) endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice. |
| format | Article |
| id | doaj-art-096c261dc53c4023a49c3901a56188c6 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-096c261dc53c4023a49c3901a56188c62025-02-03T05:51:48ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/904141904141Evaluation of the EndoPAT as a Tool to Assess Endothelial FunctionM. Moerland0A. J. Kales1L. Schrier2M. G. J. van Dongen3D. Bradnock4J. Burggraaf5Centre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsCentre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsCentre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsCentre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsCentre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsCentre for Human Drug Research, Department of Vascular Medicine, Zernikefdreef 10, 2333 CL Leiden, The NetherlandsEndothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions. We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive measurements and assessed its discriminating power in different populations. Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%). Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05). The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46). This suggests that at present the EndoPAT might not be suitable to assess (changes in) endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.http://dx.doi.org/10.1155/2012/904141 |
| spellingShingle | M. Moerland A. J. Kales L. Schrier M. G. J. van Dongen D. Bradnock J. Burggraaf Evaluation of the EndoPAT as a Tool to Assess Endothelial Function International Journal of Vascular Medicine |
| title | Evaluation of the EndoPAT as a Tool to Assess Endothelial Function |
| title_full | Evaluation of the EndoPAT as a Tool to Assess Endothelial Function |
| title_fullStr | Evaluation of the EndoPAT as a Tool to Assess Endothelial Function |
| title_full_unstemmed | Evaluation of the EndoPAT as a Tool to Assess Endothelial Function |
| title_short | Evaluation of the EndoPAT as a Tool to Assess Endothelial Function |
| title_sort | evaluation of the endopat as a tool to assess endothelial function |
| url | http://dx.doi.org/10.1155/2012/904141 |
| work_keys_str_mv | AT mmoerland evaluationoftheendopatasatooltoassessendothelialfunction AT ajkales evaluationoftheendopatasatooltoassessendothelialfunction AT lschrier evaluationoftheendopatasatooltoassessendothelialfunction AT mgjvandongen evaluationoftheendopatasatooltoassessendothelialfunction AT dbradnock evaluationoftheendopatasatooltoassessendothelialfunction AT jburggraaf evaluationoftheendopatasatooltoassessendothelialfunction |